Name: | Vecuronium Bromide |
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PubChem Compound ID: | 10415356 |
Description: | Monoquaternary homolog of PANCURONIUM. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents. |
Molecular formula: | C34H57N2O4+ |
Molecular weight: | 557.827 g/mol |
Name: | Vecuronium Bromide |
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Name (isomeric): | DB01339 |
Drug Type: | small molecule |
Description: | Monoquaternary homolog of PANCURONIUM. A non-depolarizing neuromuscular blocking agent with shorter duration of action than pancuronium. Its lack of significant cardiovascular effects and lack of dependence on good kidney function for elimination as well as its short duration of action and easy reversibility provide advantages over, or alternatives to, other established neuromuscular blocking agents. |
Category: | Neuromuscular Nondepolarizing Agents, Nicotinic Antagonists |
CAS number: | 50700-72-6 |
Indication: | Vecuronium is a muscle relaxing agent and is used as an ajunct in general anesthesia. |
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Pharmacology: | Vecuronium operates by competing for the cholinoceptors at the motor end plate thereby exerting its muscle-relaxing properties which are used adjunctively to general anesthesia. |
Mechanism of Action: |
Vecuronium is a bisquaternary nitrogen compound that acts by competitively binding to nicotinic cholinergic receptors. The binding of vecuronium decreases the opportunity for acetylcholine to bind to the nicotinic receptor at the postjunctional membrane of the myoneural junction. As a result, depolarization is prevented, calcium ions are not releas...
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Biotransformation: | 100% |
Route of elimination: | Fecal (40-75%) and renal (30% as unchanged drug and metabolites) |
Half Life: | 51–80 minutes |
Drug interaction: |
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