W2 domain QuickView - Correlation Engine

Description:: Translation initiation is a sophisticated, well regulated and highlycoordinated cellular process in eukaryotes, in which at least 11 eukayroticinitiation factors (eIFs) are included. The W2 domain (two invarianttryptophans) is a region of ~165 amino acids which is found in the C terminusof the following eIFs: Eukaryotic translation initiation factor 2B epsilon (eIF-2B-epsilon). Eukaryotic translation initiation factor 4 gamma (eIF-4-gamma). Eukaryotic translation initiation factor 5 (eIF-5), a GTPase-activating protein (GAP) specific for eIF2.The W2 domain has a globular fold and is exclusively composed out of alpha-helices. The structure can be divided into a structuralC-terminal core onto which the two N-terminal helices are attached. The corecontains two aromatic/acidic residue-rich regions (AA boxes), which areimportant for mediating protein-protein interactions.

QuickView for W2 domain (biogroup)