QuickView for WARS2 (gene)

Gene Symbol:

WARS2 Homo sapiens

Full name:

tryptophanyl tRNA synthetase 2, mitochondrial

Synonyms:

NEMMLAS, TrpRS, tryptophan--tRNA ligase, mitochondrial, (Mt)TrpRS, tryptophan tRNA ligase 2, mitochondrial

Genomic Location:

Chr 1: 119375362-119484818

Description:

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic...

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Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

POU6F1_01 ,  EFC_Q6 ,  MIF1_01 ,  STAT6_01 ,  GGTGAAG_MIR412 ,  CAGGTG_E12_Q6 ,  GGGCGGR_SP1_Q6 ,  CART1_01 ,  RYTGCNNRGNAAC_MIF1_01

Cytogenetic Map:

1p12

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