QuickView for WNK3 (gene)

Gene Symbol:

WNK3 Homo sapiens

Full name:

WNK lysine deficient protein kinase 3

Synonyms:

PRKWNK3, serine/threonine-protein kinase WNK3, protein kinase with no lysine 3

Genomic Location:

Chr X: 54239580-54401163

Description:

This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the inc...

View Full Description

This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TACTTGA_MIR26A_MIR26B ,  TTGCACT_MIR130A_MIR301_MIR130B ,  CAGGTA_AREB6_01 ,  ATTCTTT_MIR186 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  AATGTGA_MIR23A_MIR23B ,  TTGTTT_FOXO4_01 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  CAGCCTC_MIR4855P ,  ACAGGGT_MIR10A_MIR10B ,  ACCATTT_MIR522 ,  ACACTGG_MIR199A_MIR199B

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-134 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-485-5p ,  Predicted Gene Targets for miR-539

View More

View Less

Cytogenetic Map:

Xp11.22

search → result