QuickView for WNK4 (gene)

Gene Symbol:

WNK4 Homo sapiens

Full name:

WNK lysine deficient protein kinase 4

Synonyms:

PHA2B, PRKWNK4, serine/threonine-protein kinase WNK4, protein kinase lysine-deficient 4, protein kinase with no lysine 4

Genomic Location:

Chr 17: 38186222-38202610

Description:

This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux ...

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This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  FXR_Q3 ,  AML_Q6 ,  TTCNRGNNNNTTC_HSF_Q6 ,  AAGCAAT_MIR137 ,  AP2ALPHA_01 ,  COMP1_01 ,  GGGAGGRR_MAZ_Q6 ,  TFIII_Q6 ,  AP2_Q6_01 ,  HNF4_Q6 ,  TGCTGAY_UNKNOWN ,  HSF_Q6 ,  TGTTTGY_HNF3_Q6 ,  RACCACAR_AML_Q6 ,  CTGCAGY_UNKNOWN ,  RYAAAKNNNNNNTTGW_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  COREBINDINGFACTOR_Q6 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-137

Cytogenetic Map:

17q21.2

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