QuickView for WNT1 (gene)

Gene Symbol:

WNT1 Homo sapiens

Full name:

Wnt family member 1

Synonyms:

BMND16, INT1, OI15, proto-oncogene Wnt-1, proto-oncogene Int-1 homolog, wingless-type MMTV integration site family member 1, wingless-type MMTV integration site family, member 1 (oncogene INT1)

Genomic Location:

Chr 12: 47658503-47662746

Description:

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and th...

View Full Description

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein at the amino acid level. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome. This gene is clustered with another family member, WNT10B, in the chromosome 12q13 region.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  TTTGCAC_MIR19A_MIR19B ,  MCAATNNNNNGCG_UNKNOWN ,  MAZR_01 ,  ZF5_01 ,  CATTGTYY_SOX9_B1 ,  NGFIC_01 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  MYCMAX_B ,  EGR2_01 ,  WHN_B ,  GGGAGGRR_MAZ_Q6 ,  STAT_Q6 ,  CEBP_01 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  GGGCGGR_SP1_Q6 ,  AP2_Q3 ,  AP2_Q6 ,  SCGGAAGY_ELK1_02 ,  WTTGKCTG_UNKNOWN ,  SMAD4_Q6 ,  YRCCAKNNGNCGC_UNKNOWN ,  AAACCAC_MIR140 ,  EGR3_01 ,  SP1_Q2_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-140

Cytogenetic Map:

12q13.12

search → result