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QuickView for WNT5A (gene)


Gene Symbol:
WNT5A Homo sapiens Homo sapiens
Full name:
Wnt family member 5A
Synonyms:
hWNT5A, protein Wnt-5a, WNT-5A protein, wingless-type MMTV integration site family, member 5A
Genomic Location:
Chr 3: 55474783-55496371
Description:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical an...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
TGGAAA_NFAT_Q4_01 CTTGTAT_MIR381 SP1_01 HNF3ALPHA_Q6 CEBPA_01 GATA1_01 TGGNNNNNNKCCAR_UNKNOWN HFH3_01 ATGTCAC_MIR489 POU3F2_01
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 3
3p14.3





GO Molecular Function

transcription regulatory region DNA binding | nucleic acid binding | lipid binding | signaling receptor binding | phospholipid binding | molecular function regulator | protein domain specific binding | frizzled binding | anion binding | DNA binding | receptor tyrosine kinase-like orphan receptor binding | ion binding | organic cyclic compound binding | chemoattractant activity involved in axon guidance | protein binding | receptor regulator activity | DNA-binding transcription factor activity | G-protein coupled receptor binding | receptor ligand activity | cytokine activity | chemoattractant activity | heterocyclic compound binding

GO Biological Process

positive regulation of immune response | regulation of JUN kinase activity | regulation of leukocyte chemotaxis | brain development | limb development | positive regulation of macrophage cytokine production | non-canonical Wnt signaling pathway via MAPK cascade | regulation of interleukin-1 beta production | cell morphogenesis | olfactory bulb interneuron differentiation | inner ear morphogenesis | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | planar cell polarity pathway involved in ventricular septum morphogenesis | activation of GTPase activity | negative regulation of embryonic development | response to cytokine | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of protein localization to synapse | regulation of neurogenesis | neuron projection morphogenesis | response to lipopolysaccharide | developmental process involved in reproduction | regulation of cellular localization | muscle tissue development | intracellular signal transduction | regulation of synapse assembly | positive regulation of apoptotic process | mesenchymal-epithelial cell signaling | regulation of cell development | regulation of localization | mammary gland duct morphogenesis | morphogenesis of an epithelium | positive regulation of DNA-binding transcription factor activity | regulation of axon extension involved in axon guidance | gonad development | regulation of programmed cell death | positive regulation of peptidyl-threonine phosphorylation | eye development | forebrain morphogenesis | regulation of meiotic cell cycle | paraxial mesoderm morphogenesis | regulation of immune system process | negative regulation of BMP signaling pathway | positive regulation of protein localization to synapse | negative regulation of cellular process | positive regulation of developmental process | embryonic camera-type eye morphogenesis | regulation of MAP kinase activity | epithelial cell proliferation involved in mammary gland duct elongation | negative regulation of RNA biosynthetic process | embryonic appendage morphogenesis | response to metal ion | cell differentiation | positive regulation of epithelial cell proliferation | positive regulation of fibroblast proliferation | respiratory tube development | hindgut development | defense response | negative regulation of fat cell differentiation | nervous system development | epithelial to mesenchymal transition | positive regulation of protein catabolic process | type B pancreatic cell differentiation | melanocyte proliferation | cell part morphogenesis | neurogenesis | positive regulation of interleukin-1 beta secretion | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | planar cell polarity pathway involved in cardiac right atrium morphogenesis | regulation of organelle organization | positive regulation of endothelial cell proliferation | positive regulation of cellular component movement | convergent extension | establishment or maintenance of apical/basal cell polarity | generation of neurons | positive regulation of protein secretion | membrane organization | mesenchyme development | non-canonical Wnt signaling pathway involved in heart development | planar cell polarity pathway involved in axon guidance | cardiac atrium morphogenesis | pattern specification process | regulation of neuron death | positive regulation of GTPase activity | positive regulation of cellular biosynthetic process | cellular process | negative regulation of axonogenesis | positive regulation of cartilage development | regulation of cytokine biosynthetic process | regulation of cell motility | localization | cell projection morphogenesis | cervix development | epithelial tube morphogenesis | limb morphogenesis | mesoderm morphogenesis | heart morphogenesis | type B pancreatic cell development | negative regulation of signaling | developmental growth | positive regulation of immune effector process | negative regulation of synapse organization | positive regulation of peptidyl-serine phosphorylation | neuron development | negative regulation of developmental growth | central nervous system neuron differentiation | determination of left/right symmetry | notochord morphogenesis | reproductive system development | synapse assembly | canonical Wnt signaling pathway | mesoderm development | optic cup morphogenesis involved in camera-type eye development | positive regulation of macrophage activation | regulation of embryonic development | immune system development | hindgut morphogenesis | negative regulation of nucleic acid-templated transcription | negative regulation of mesenchymal cell proliferation | positive regulation of protein kinase activity | macromolecule localization | regulation of response to cytokine stimulus | regulation of chemotaxis | glandular epithelial cell differentiation | negative regulation of apoptotic process | digestive tract morphogenesis | axon guidance | positive regulation of T cell apoptotic process | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | serotonergic neuron axon guidance | positive regulation of nitrogen compound metabolic process | forebrain neuron differentiation | Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation | regulation of neuron projection development | diencephalon development | response to inorganic substance | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of fat cell differentiation | dopaminergic neuron axon guidance | regulation of cell differentiation | muscle structure development | ventricular septum morphogenesis | cellular response to retinoic acid | regulation of lymphocyte apoptotic process | regulation of angiogenesis | positive regulation of interleukin-8 production | inhibitory synapse assembly | morphogenesis of a polarized epithelium | regulation of immune response | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | pituitary gland development | positive regulation of stress-activated MAPK cascade | cardiac right atrium morphogenesis | negative regulation of chemotaxis | negative regulation of fibroblast growth factor receptor signaling pathway | cellular response to molecule of bacterial origin | polarized epithelial cell differentiation | positive regulation of interferon-gamma production | positive regulation of cellular protein metabolic process | positive regulation of hair cycle | epithelium development | regulation of axon guidance | regulation of establishment of planar polarity | establishment of cell polarity | endocrine pancreas development | cellular component organization | negative regulation of cell morphogenesis involved in differentiation | MAPK cascade | response to transforming growth factor beta | planar cell polarity pathway involved in heart morphogenesis | cellular response to metal ion | urogenital system development | positive regulation of protein binding | positive regulation of epithelial cell migration | cellular response to interferon-gamma | positive regulation of tumor necrosis factor production | mammary gland morphogenesis | development of primary sexual characteristics | head development | positive regulation of type I interferon-mediated signaling pathway | regulation of peptide secretion | positive regulation of stress-activated protein kinase signaling cascade | muscle organ morphogenesis | regulation of vasculature development | response to stimulus | positive regulation of interleukin-1 beta production | cell morphogenesis involved in neuron differentiation | regulation of cellular protein localization | regulation of interleukin-8 secretion | embryonic limb morphogenesis | midgut development | respiratory system development | JNK cascade | positive regulation of innate immune response | planar cell polarity pathway involved in cardiac muscle tissue morphogenesis | paraxial mesoderm development | embryonic epithelial tube formation | positive regulation of immune system process | positive regulation of protein metabolic process | non-canonical Wnt signaling pathway via JNK cascade | signal transduction by protein phosphorylation | positive regulation of protein kinase C signaling | determination of heart left/right asymmetry | mesoderm formation | gland morphogenesis | response to stress | neuron projection guidance | positive regulation of chemokine biosynthetic process | hypophysis morphogenesis | positive regulation of T cell migration | regulation of cell proliferation | negative regulation of neuron projection development | roof of mouth development | tube morphogenesis | cardiac muscle tissue development | planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation | positive regulation of cell-cell adhesion | muscle tissue morphogenesis | epithelial cell development | positive regulation of protein kinase C activity | positive regulation of thymocyte apoptotic process | positive regulation of cytokine biosynthetic process | positive regulation of cell activation | epithelial tube formation | reproduction | cellular response to inorganic substance | cellular localization | embryonic skeletal system development | non-canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation | positive regulation of cytokine secretion | midbrain development | response to molecule of bacterial origin | axis elongation | blastoderm segmentation | chemorepulsion of axon | regulation of protein transport | brain morphogenesis | positive regulation of meiotic cell cycle | negative regulation of metabolic process | regulation of cellular component size | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | hemopoiesis | cellular component assembly | regulation of axon extension | protein modification process | pericardium development | cartilage development | regulation of synapse structure or activity | positive regulation of hair follicle development | regulation of peptide transport | regulation of cell adhesion | Wnt signaling pathway, planar cell polarity pathway | embryo development | regulation of morphogenesis of a branching structure | macromolecule modification | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | cell-cell signaling | planar cell polarity pathway involved in gastrula mediolateral intercalation | activation of protein kinase activity | molecular function regulator | cell surface receptor signaling pathway involved in cell-cell signaling | positive chemotaxis | stress-activated protein kinase signaling cascade | anterior/posterior pattern specification | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | regulation of cellular response to stress | locomotion | positive regulation of response to cytokine stimulus | central nervous system neuron development | response to external biotic stimulus | optic cup formation involved in camera-type eye development | system development | nitrogen compound metabolic process | enteroendocrine cell differentiation | reproductive process | regulation of signal transduction | positive regulation of organelle organization | Wnt signaling pathway | negative regulation of growth | positive regulation of neuron projection development | lateral sprouting involved in mammary gland duct morphogenesis | regulation of cartilage development | multicellular organism development | cell migration | olfactory bulb interneuron development | positive regulation of tumor necrosis factor secretion | regulation of MAPK cascade | regulation of BMP signaling pathway | phosphorus metabolic process | positive regulation of inflammatory response | mammary gland development | regulation of axonogenesis | chemoattraction of serotonergic neuron axon | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | vagina development | forebrain neuron development | regulation of phosphorylation | regulation of ossification | positive regulation of lymphocyte migration | wound healing | telencephalon development | positive regulation of cell cycle | determination of bilateral symmetry | regulation of neuron differentiation | regulation of gene expression | positive regulation of chemotaxis | lateral sprouting from an epithelium | stem cell proliferation | convergent extension involved in organogenesis | pancreas development | axon development | positive regulation of secretion | neural tube closure | outflow tract morphogenesis | cellular response to stress | response to lipid | embryonic axis specification | regulation of epidermis development | regulation of fibroblast growth factor receptor signaling pathway | embryonic heart tube morphogenesis | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | animal organ morphogenesis | regulation of cell-cell adhesion mediated by cadherin | regulation of synapse organization | regulation of nitrogen compound metabolic process | olfactory lobe development | regulation of cell migration | positive regulation of JNK cascade | cardiac atrium development | positive regulation of cell projection organization | negative regulation of cellular response to growth factor stimulus | establishment or maintenance of monopolar cell polarity | positive regulation of intracellular signal transduction | neural tube formation | regulation of hair follicle development | regulation of cellular component movement | regulation of transcription by RNA polymerase II | morphogenesis of an epithelial sheet | synapse organization | axonogenesis | positive regulation of hydrolase activity | positive regulation of neuron projection arborization | positive regulation of cell differentiation | regulation of endothelial cell migration | activation of protein kinase B activity | non-canonical Wnt signaling pathway | epidermal cell differentiation | embryonic camera-type eye development | positive regulation of cell migration | cellular response to cytokine stimulus | cell proliferation | stress-activated MAPK cascade | neural tube development | regulation of cellular protein metabolic process | positive regulation of ossification | mesenchyme morphogenesis | positive regulation of non-canonical Wnt signaling pathway | regulation of melanin biosynthetic process | planar cell polarity pathway involved in outflow tract morphogenesis | phosphorylation | cardiac septum morphogenesis | positive regulation of interleukin-1 secretion | digestive tract development | convergent extension involved in axis elongation | mammary gland epithelial cell proliferation | glandular epithelial cell development | positive regulation of neuron death | heart looping | positive regulation of chemokine production | epidermis development | positive regulation of leukocyte apoptotic process | regulation of GTPase activity | skin development | mediolateral intercalation | endocrine system development | protein phosphorylation | regulation of tumor necrosis factor production | cell morphogenesis involved in differentiation | keratinocyte differentiation | postsynapse assembly | establishment or maintenance of cell polarity | regulation of leukocyte migration | phosphate-containing compound metabolic process | sensory organ development | gastrulation with mouth forming second | regulation of macrophage activation | response to bacterium | regulation of interleukin-1 production | chordate embryonic development | striated muscle tissue development | regulation of timing of anagen | cardiac muscle tissue morphogenesis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | eye morphogenesis | female genitalia development | olfactory bulb development | positive regulation of interleukin-1 production | hematopoietic stem cell proliferation | anterior/posterior axis specification | positive regulation of leukocyte chemotaxis | regulation of T cell apoptotic process | chemoattractant activity involved in axon guidance | regulation of T cell migration | planar cell polarity pathway involved in pericardium morphogenesis | regulation of cytokine production involved in immune response | regulation of protein kinase C signaling | regulation of protein metabolic process | positive regulation of signal transduction | inner ear development | heart development | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | cochlea morphogenesis | renal system development | positive regulation of transport | genitalia development | response to retinoic acid | positive regulation of meiotic nuclear division | establishment of planar polarity | negative regulation of cell growth | regulation of cellular response to growth factor stimulus | embryonic morphogenesis | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | notochord development | regulation of cytokine secretion | secondary palate development | neuron differentiation | diencephalon morphogenesis | activation of MAPK activity | embryonic organ morphogenesis | presynapse assembly | positive regulation of myeloid leukocyte cytokine production involved in immune response | Wnt signaling pathway, calcium modulating pathway | regulation of signaling receptor activity | receptor regulator activity | development of primary male sexual characteristics | regulation of cell morphogenesis involved in differentiation | ventricular septum development | negative regulation of epithelial cell proliferation | protein metabolic process | regulation of fibroblast proliferation | positive regulation of cell-cell adhesion mediated by cadherin | DNA-binding transcription factor activity | regulation of establishment of protein localization | regionalization | cardiac ventricle development | axis specification | positive regulation of protein modification process | regulation of growth | cellular response to calcium ion | response to organic substance | gland development | regulation of innate immune response | regulation of meiotic nuclear division | negative regulation of cell projection organization | tissue morphogenesis | negative regulation of axon extension involved in axon guidance | digestive system development | regulation of prostatic bud formation | branching morphogenesis of an epithelial tube | epithelial cell proliferation | regulation of kinase activity | male sex differentiation | response to wounding | regulation of animal organ morphogenesis | regulation of establishment of planar polarity involved in neural tube closure | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | post-anal tail morphogenesis | establishment of tissue polarity | embryonic heart tube development | anatomical structure development | developmental growth involved in morphogenesis | branch elongation of an epithelium | cell surface receptor signaling pathway | positive regulation of neurogenesis | regulation of neural precursor cell proliferation | cell projection organization | metabolic process | positive regulation of cell development | cell fate commitment | mesenchymal cell differentiation | regulation of protein catabolic process | regulation of interleukin-1 beta secretion | regulation of thymocyte apoptotic process | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | establishment or maintenance of epithelial cell apical/basal polarity | primitive streak formation | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | embryonic organ development | male gonad development | development of secondary sexual characteristics | regulation of cytokine secretion involved in immune response | positive regulation of cytokine production involved in immune response | mesodermal to mesenchymal transition involved in gastrulation | cellular protein localization | ear development | regulation of vesicle-mediated transport | negative regulation of axon extension | forebrain generation of neurons | regulation of secretion | positive regulation of cell death | morphogenesis of embryonic epithelium | receptor ligand activity | development of secondary female sexual characteristics | positive regulation of interleukin-6 production | immune response | positive regulation of interleukin-8 secretion | establishment of monopolar cell polarity | midbrain dopaminergic neuron differentiation | positive regulation of T cell chemotaxis | neuron projection development | regulation of non-canonical Wnt signaling pathway | embryonic camera-type eye formation | cytokine activity | organic substance metabolic process | connective tissue development | negative regulation of biosynthetic process | chemoattractant activity | regulation of type I interferon-mediated signaling pathway | negative regulation of gene expression | animal organ development | regulation of endothelial cell proliferation | forebrain development | negative regulation of neuron differentiation | establishment of epithelial cell polarity | regulation of cell activation | negative regulation of cellular component movement | mammary gland branching involved in thelarche | positive regulation of NF-kappaB transcription factor activity | regulation of protein secretion | positive regulation of leukocyte migration | positive regulation of G-protein coupled receptor protein signaling pathway | anterior/posterior axis specification, embryo | positive regulation of programmed cell death | positive regulation of kinase activity | regulation of tumor necrosis factor secretion | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | pericardium morphogenesis | positive regulation of cytokine secretion involved in immune response | mammary gland epithelium development | positive regulation of binding | response to interferon-gamma | positive regulation of cytokine production | dopaminergic neuron differentiation | regulation of JNK cascade | positive regulation of endothelial cell migration | positive regulation of MAPK cascade | negative regulation of melanin biosynthetic process | positive regulation of timing of anagen | lung development | positive regulation of lymphocyte apoptotic process | regulation of lymphocyte chemotaxis | morphogenesis of a branching epithelium | positive regulation of protein transport | camera-type eye development | positive regulation of canonical Wnt signaling pathway | regulation of peptidyl-serine phosphorylation | planar cell polarity pathway involved in axis elongation | anatomical structure formation involved in morphogenesis | uterus development | excitatory synapse assembly | regulation of epithelial cell migration | regulation of animal organ formation | convergent extension involved in gastrulation | establishment of apical/basal cell polarity | positive regulation of cytokine-mediated signaling pathway | regulation of stress-activated MAPK cascade | regulation of cell communication | paraxial mesoderm formation | negative regulation of signal transduction | signaling | somite development | regulation of transcription, DNA-templated | regulation of protein binding | cell development | embryonic digit morphogenesis | regulation of endocytosis | regulation of developmental growth | protein localization | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cell migration involved in gastrulation | cellular protein metabolic process | regulation of cell size | regulation of cytokine production | morphogenesis of a branching structure | anatomical structure morphogenesis | cellular macromolecule localization | camera-type eye morphogenesis | positive regulation of MAP kinase activity | response to biotic stimulus | reproductive structure development | regulation of nervous system development | regulation of developmental process | regulation of G-protein coupled receptor protein signaling pathway | segmentation | regulation of mesenchymal cell proliferation | developmental process | negative regulation of canonical Wnt signaling pathway | positive regulation of cell cycle process | regulation of cell growth | cardiac septum development | cellular protein modification process | branch elongation involved in mammary gland duct branching | regulation of chemokine production | columnar/cuboidal epithelial cell development | negative chemotaxis | tube development | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation in midbrain | negative regulation of cell proliferation | regulation of cell-cell adhesion | regulation of hair cycle | urinary bladder development | negative regulation of neural precursor cell proliferation | innate immune response | positive regulation of mesenchymal cell proliferation | negative regulation of prostatic bud formation | positive regulation of nucleic acid-templated transcription | cochlea development | tube closure | epithelial cell differentiation | formation of primary germ layer | positive regulation of transcription by RNA polymerase II | positive regulation of epidermis development | cardiac chamber development | somitogenesis | tube formation | positive regulation of JUN kinase activity | response to calcium ion | central nervous system development | positive regulation of metabolic process | negative regulation of Wnt signaling pathway | positive regulation of neuron differentiation | regulation of branching involved in mammary gland duct morphogenesis | chemorepulsion of dopaminergic neuron axon | regulation of cell projection organization | regulation of interferon-gamma production | skeletal system development | gastrulation | immune system process | positive regulation of Wnt signaling pathway | cellular metabolic process | hematopoietic or lymphoid organ development | embryonic eye morphogenesis | chemoattraction of axon | female sex differentiation | ameboidal-type cell migration | cellular response to organic substance | regulation of protein localization | regulation of cell death | sex differentiation | activation of JUN kinase activity | positive regulation of cell motility | establishment of epithelial cell apical/basal polarity | negative regulation of cell death | negative regulation of cell development | regulation of interleukin-6 production | circulatory system development | regulation of inflammatory response | branching involved in mammary gland duct morphogenesis | chemotaxis | ear morphogenesis | negative regulation of synapse assembly | negative regulation of locomotion | positive regulation of endocytosis | positive regulation of angiogenesis | regulation of lymphocyte migration | regulation of I-kappaB kinase/NF-kappaB signaling | negative regulation of cell differentiation | regulation of cellular component organization | lens development in camera-type eye | muscle organ development | response to other organism | positive regulation of signaling | regulation of T cell chemotaxis | signal transduction | regulation of signaling | positive regulation of gene expression | embryonic pattern specification | cellular response to growth factor stimulus | planar cell polarity pathway involved in neural tube closure | cellular response to lipopolysaccharide | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | face development | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | clathrin-coated endocytic vesicle membrane | extracellular matrix | endocytic vesicle membrane | clathrin-coated vesicle membrane | organelle membrane | clathrin-coated vesicle | cytoplasmic vesicle | cell | cytoplasm | clathrin-coated endocytic vesicle | intracellular organelle | endoplasmic reticulum | Golgi apparatus | endomembrane system | plasma membrane | vesicle | endoplasmic reticulum lumen | extracellular exosome | extracellular region | coated vesicle membrane | membrane-bounded organelle | extracellular vesicle | organelle | vesicle membrane | extracellular space | cell periphery | membrane-enclosed lumen | intracellular vesicle | cell surface | endocytic vesicle | intracellular | membrane | cytoplasmic vesicle membrane | Golgi lumen | coated vesicle