QuickView for WWP2;jsessionid=3D4D7746C6F752CE93DDD7660CDE2C41 (gene)
- Gene Symbol:
- WWP2
Homo sapiens - Full name:
- WW domain containing E3 ubiquitin protein ligase 2
- Synonyms:
- AIP2, WWp2-like, NEDD4-like E3 ubiquitin-protein ligase WWP2, HECT-type E3 ubiquitin transferase WWP2, atrophin-1 interacting protein 2
- Genomic Location:
- Chr 16: 68353775-68533144
- Description:
-
This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Al...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
TGGAAA_NFAT_Q4_01 , PR_Q2 , POU6F1_01 , PAX4_04 , CGGAARNGGCNG_UNKNOWN , GATA1_03 , RYTTCCTG_ETS2_B , AREB6_02 , AP3_Q6 , CACGTG_MYC_Q2
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
16q22.1
GO Molecular Function
transcription factor activity, transcription factor binding | transcription factor activity, RNA polymerase II transcription factor binding | catalytic activity | ubiquitin-like protein transferase activity | ubiquitin protein ligase activity | protein binding | transcriptional activator activity, RNA polymerase II transcription factor binding | transcription factor binding | RNA polymerase II transcription factor binding | ubiquitin-protein transferase activity | transferase activity | ubiquitin-like protein ligase activity
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | transcription factor activity, transcription factor binding | positive regulation of macromolecule biosynthetic process | proteolysis | regulation of localization | establishment of localization | negative regulation of cellular process | negative regulation of RNA biosynthetic process | positive regulation of protein catabolic process | positive regulation of cellular biosynthetic process | cellular process | protein K63-linked ubiquitination | organic substance catabolic process | localization | proteolysis involved in cellular protein catabolic process | negative regulation of signaling | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | transcription factor activity, RNA polymerase II transcription factor binding | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | interspecies interaction between organisms | regulation of cellular process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | entry into host cell | viral life cycle | negative regulation of protein transport | positive regulation of protein metabolic process | cellular nitrogen compound biosynthetic process | negative regulation of transporter activity | cellular protein catabolic process | cellular nitrogen compound metabolic process | proteasomal protein catabolic process | negative regulation of transport | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | regulation of peptide transport | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | regulation of potassium ion transmembrane transport | regulation of membrane potential | nitrogen compound metabolic process | regulation of signal transduction | regulation of gene expression | viral entry into host cell | protein catabolic process | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of Notch signaling pathway | negative regulation of DNA-binding transcription factor activity | regulation of transcription by RNA polymerase II | ubiquitin protein ligase activity | biosynthetic process | aromatic compound biosynthetic process | regulation of potassium ion transmembrane transporter activity | regulation of cellular metabolic process | regulation of protein metabolic process | regulation of RNA metabolic process | viral process | proteasome-mediated ubiquitin-dependent protein catabolic process | regulation of potassium ion transport | protein polyubiquitination | transcriptional activator activity, RNA polymerase II transcription factor binding | protein metabolic process | regulation of establishment of protein localization | protein ubiquitination | regulation of DNA-binding transcription factor activity | cellular macromolecule catabolic process | protein autoubiquitination | metabolic process | ubiquitin-protein transferase activity | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | protein modification by small protein conjugation or removal | regulation of ion transmembrane transport | extracellular transport | transcription, DNA-templated | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | regulation of transcription, DNA-templated | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | cellular protein metabolic process | cellular macromolecule biosynthetic process | regulation of ion transport | cellular protein modification process | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | negative regulation of Notch signaling pathway | cellular metabolic process | regulation of protein localization | modification-dependent protein catabolic process | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | catalytic complex | cell | cytoplasm | intracellular organelle | ubiquitin ligase complex | protein-containing complex | vesicle | transferase complex | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cytosol | intracellular | membrane
