QuickView for Wave2 (gene)

Gene Symbol:

WASF2 Homo sapiens

Full name:

WAS protein family member 2

Synonyms:

IMD2, SCAR2, WASF4, WAVE2, dJ393P12.2, wiskott-Aldrich syndrome protein family member 2, WASP family Verprolin-homologous protein 2, WASP family protein member 2, WASP family protein member 4, protein WAVE-2, putative Wiskott-Aldrich syndrome protein family member 4, suppressor of cyclic-AMP receptor (WASP-family), verprolin homology domain-containing protein 2

Genomic Location:

Chr 1: 27604713-27689256

Description:

This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in ce...

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This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  RTAAACA_FREAC2_01 ,  TGANTCA_AP1_C ,  TTANTCA_UNKNOWN ,  P53_DECAMER_Q2 ,  NFY_C ,  PEA3_Q6 ,  TTTGTAG_MIR520D ,  FAC1_01 ,  IRF1_Q6 ,  TTF1_Q6 ,  ATGGYGGA_UNKNOWN ,  E2F1_Q4 ,  CTTTGTA_MIR524 ,  GGGYGTGNY_UNKNOWN ,  TITF1_Q3 ,  ALPHACP1_01 ,  AP1_01 ,  GR_Q6 ,  GGGCGGR_SP1_Q6 ,  NFY_01 ,  AP1_Q2_01 ,  NFY_Q6 ,  TTGCCAA_MIR182 ,  BACH1_01 ,  SCGGAAGY_ELK1_02 ,  RGAGGAARY_PU1_Q6 ,  SMAD4_Q6 ,  AGGGCAG_MIR18A ,  CTTTGT_LEF1_Q2 ,  AACTTT_UNKNOWN ,  PAX4_03 ,  GGCAGTG_MIR3243P ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-146 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182

Cytogenetic Map:

1p36.11

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