QuickView for Wnk1 (gene)

Gene Symbol:

WNK1 Homo sapiens

Full name:

WNK lysine deficient protein kinase 1

Synonyms:

HSAN2, HSN2, KDP, PPP1R167, PRKWNK1, PSK, p65, serine/threonine-protein kinase WNK1, WNK lysine deficient protein kinase 1 isoform, erythrocyte 65 kDa protein, prostate-derived sterile 20-like kinase, protein kinase with no lysine 1, protein phosphatase 1, regulatory subunit 167, serine/threonine-protein kinase WNK1 1, serine/threonine-protein kinase WNK1 2

Genomic Location:

Chr 12: 732486-890879

Description:

This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced ...

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This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  YTCCCRNNAGGY_UNKNOWN ,  TTANTCA_UNKNOWN ,  CTTTGA_LEF1_Q2 ,  GGGAGGRR_MAZ_Q6 ,  CDPCR3HD_01 ,  AP2_Q6_01 ,  GGGCGGR_SP1_Q6 ,  ACTAYRNNNCCCR_UNKNOWN ,  NKX61_01 ,  TGCCAAR_NF1_Q6 ,  SOX5_01 ,  PTF1BETA_Q6 ,  YCATTAA_UNKNOWN ,  AP2_Q6 ,  CEBP_Q3 ,  AFP1_Q6 ,  RCGCANGCGY_NRF1_Q6 ,  HNF1_Q6 ,  HNF6_Q6

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Cytogenetic Map:

12p13.33

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