QuickView for XPO1;jsessionid=1CC06D7A04845C52183B5DE9FB1D9685 (gene)

Gene Symbol:

XPO1 Homo sapiens

Full name:

exportin 1

Synonyms:

CRM1, emb, exp1, exportin-1, chromosome region maintenance 1 homolog, chromosome region maintenance 1 protein homolog, exportin 1 (CRM1 homolog, yeast), exportin-1 (required for chromosome region maintenance)

Genomic Location:

Chr 2: 61558573-61618922

Description:

This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protei...

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This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  DR3_Q4 ,  MZF1_01 ,  ARNT_01 ,  VDR_Q3 ,  ATGTCAC_MIR489 ,  TTTTGAG_MIR373 ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  TTCNRGNNNNTTC_HSF_Q6 ,  GCANCTGNY_MYOD_Q6 ,  MAX_01 ,  ATF4_Q2 ,  HP1SITEFACTOR_Q6 ,  VDR_Q6 ,  AREB6_04 ,  WGTTNNNNNAAA_UNKNOWN ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  AGGAGTG_MIR483 ,  MYB_Q5_01 ,  GGGAGGRR_MAZ_Q6 ,  GGGNRMNNYCAT_UNKNOWN ,  TFIII_Q6 ,  MYCMAX_02 ,  RGAANNTTC_HSF1_01 ,  SREBP1_01 ,  CACCCBINDINGFACTOR_Q6 ,  GGGYGTGNY_UNKNOWN ,  YYCATTCAWW_UNKNOWN ,  NFY_Q6_01 ,  ALPHACP1_01 ,  TTCYRGAA_UNKNOWN ,  CAGCTTT_MIR320 ,  NKX62_Q2 ,  GGGCGGR_SP1_Q6 ,  NFY_01 ,  SPZ1_01 ,  USF_01 ,  KCCGNSWTTT_UNKNOWN ,  ACTWSNACTNY_UNKNOWN ,  PTF1BETA_Q6 ,  WTTGKCTG_UNKNOWN ,  IK3_01 ,  CTGCAGY_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  PAX3_B ,  CCAATNNSNNNGCG_UNKNOWN ,  AACTTT_UNKNOWN ,  MZF1_02 ,  USF_02 ,  PAX2_02 ,  GGARNTKYCCA_UNKNOWN ,  NFKB_Q6 ,  PAX4_01 ,  ACACTAC_MIR1423P ,  MYB_Q3

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-190 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-381

Cytogenetic Map:

2p15

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