Correlation Engine 2.0
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QuickView for XPO1 (gene)


Gene Symbol:
XPO1 Homo sapiens Homo sapiens
Full name:
exportin 1
Synonyms:
CRM1, emb, exp1, exportin-1, chromosome region maintenance 1 homolog, chromosome region maintenance 1 protein homolog, exportin 1 (CRM1 homolog, yeast), exportin-1 (required for chromosome region maintenance)
Genomic Location:
Chr 2: 61558573-61618922
Description:
This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protei...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
NFAT_Q4_01 TGGAAA_NFAT_Q4_01 DR3_Q4 MZF1_01 ARNT_01 VDR_Q3 ATGTCAC_MIR489 TTTTGAG_MIR373 MYCMAX_03 CACGTG_MYC_Q2
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2
2p15





GO Molecular Function

GTPase binding | enzyme binding | nucleic acid binding | protein transporter activity | Ras GTPase binding | protein domain specific binding | transporter activity | nuclear export signal receptor activity | organic cyclic compound binding | protein binding | Ran GTPase binding | small GTPase binding | heterocyclic compound binding | RNA binding

GO Biological Process

regulation of cell cycle process | regulation of intracellular protein transport | regulation of cellular localization | nuclear export | regulation of localization | establishment of localization | negative regulation of cellular process | negative regulation of RNA biosynthetic process | response to drug | regulation of organelle organization | intracellular transport | establishment of organelle localization | localization | protein transport | negative regulation of nucleic acid-templated transcription | macromolecule localization | regulation of cell cycle | ribosome biogenesis | regulation of protein export from nucleus | establishment of localization in cell | negative regulation of cellular metabolic process | interspecies interaction between organisms | regulation of mRNA stability | regulation of cellular process | regulation of metabolic process | organelle localization | viral life cycle | protein transporter activity | protein export from nucleus | response to stimulus | regulation of cellular protein localization | regulation of centrosome cycle | intracellular protein transport | posttranscriptional regulation of gene expression | protein localization to nucleus | cellular localization | ribosomal small subunit export from nucleus | regulation of protein transport | negative regulation of metabolic process | regulation of peptide transport | ribosome localization | regulation of intracellular transport | intracellular transport of virus | regulation of nucleic acid-templated transcription | ribonucleoprotein complex localization | regulation of gene expression | organic substance transport | regulation of nitrogen compound metabolic process | peptide transport | ribosomal subunit export from nucleus | regulation of RNA stability | regulation of transcription by RNA polymerase II | protein localization to organelle | nuclear export signal receptor activity | RNA export from nucleus | mRNA transport | establishment of RNA localization | regulation of cellular metabolic process | protein-containing complex localization | regulation of protein metabolic process | regulation of RNA metabolic process | viral process | ribosomal large subunit export from nucleus | regulation of microtubule-based process | regulation of nucleocytoplasmic transport | regulation of centrosome duplication | regulation of establishment of protein localization | nucleobase-containing compound transport | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | cellular protein localization | amide transport | nuclear transport | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of mRNA catabolic process | establishment of protein localization | RNA transport | regulation of transcription, DNA-templated | protein localization | cellular macromolecule localization | nucleocytoplasmic transport | negative regulation of transcription by RNA polymerase II | regulation of transport | ribonucleoprotein complex biogenesis | regulation of protein localization | RNA localization | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of cytoskeleton organization

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | host cell | organelle membrane | nuclear membrane | chromosome, centromeric region | cell | annulate lamellae | nuclear lumen | kinetochore | nucleolus | other organism cell | cytoplasm | intracellular organelle | Cajal body | nuclear body | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | nucleoplasm | nuclear envelope | ribonucleoprotein complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular | membrane