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QuickView for XPO1 (gene)

Gene Symbol:
XPO1 Homo sapiens Homo sapiens
Full name:
exportin 1
CRM1, emb, exp1, exportin-1, chromosome region maintenance 1 homolog, chromosome region maintenance 1 protein homolog, exportin 1 (CRM1 homolog, yeast), exportin-1 (required for chromosome region maintenance)
Genomic Location:
Chr 2: 61558573-61618922
This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protei...
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2

GO Molecular Function

GTPase binding | enzyme binding | nucleic acid binding | protein transporter activity | Ras GTPase binding | protein domain specific binding | transporter activity | nuclear export signal receptor activity | organic cyclic compound binding | protein binding | Ran GTPase binding | small GTPase binding | heterocyclic compound binding | RNA binding

GO Biological Process

regulation of cell cycle process | regulation of intracellular protein transport | regulation of cellular localization | nuclear export | regulation of localization | establishment of localization | negative regulation of cellular process | negative regulation of RNA biosynthetic process | response to drug | regulation of organelle organization | intracellular transport | establishment of organelle localization | localization | protein transport | negative regulation of nucleic acid-templated transcription | macromolecule localization | regulation of cell cycle | ribosome biogenesis | regulation of protein export from nucleus | establishment of localization in cell | negative regulation of cellular metabolic process | interspecies interaction between organisms | regulation of mRNA stability | regulation of cellular process | regulation of metabolic process | organelle localization | viral life cycle | protein transporter activity | protein export from nucleus | response to stimulus | regulation of cellular protein localization | regulation of centrosome cycle | intracellular protein transport | posttranscriptional regulation of gene expression | protein localization to nucleus | cellular localization | ribosomal small subunit export from nucleus | regulation of protein transport | negative regulation of metabolic process | regulation of peptide transport | ribosome localization | regulation of intracellular transport | intracellular transport of virus | regulation of nucleic acid-templated transcription | ribonucleoprotein complex localization | regulation of gene expression | organic substance transport | regulation of nitrogen compound metabolic process | peptide transport | ribosomal subunit export from nucleus | regulation of RNA stability | regulation of transcription by RNA polymerase II | protein localization to organelle | nuclear export signal receptor activity | RNA export from nucleus | mRNA transport | establishment of RNA localization | regulation of cellular metabolic process | protein-containing complex localization | regulation of protein metabolic process | regulation of RNA metabolic process | viral process | ribosomal large subunit export from nucleus | regulation of microtubule-based process | regulation of nucleocytoplasmic transport | regulation of centrosome duplication | regulation of establishment of protein localization | nucleobase-containing compound transport | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | cellular protein localization | amide transport | nuclear transport | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of mRNA catabolic process | establishment of protein localization | RNA transport | regulation of transcription, DNA-templated | protein localization | cellular macromolecule localization | nucleocytoplasmic transport | negative regulation of transcription by RNA polymerase II | regulation of transport | ribonucleoprotein complex biogenesis | regulation of protein localization | RNA localization | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of cytoskeleton organization

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | host cell | organelle membrane | nuclear membrane | chromosome, centromeric region | cell | annulate lamellae | nuclear lumen | kinetochore | nucleolus | other organism cell | cytoplasm | intracellular organelle | Cajal body | nuclear body | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | nucleoplasm | nuclear envelope | ribonucleoprotein complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular | membrane