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QuickView for YDL134C;jsessionid=BD58E30995E8BC2A228117A3FB93C314;jsessionid=F69E662545958601C59CC65F57817667 (gene)


Gene Symbol:
Ppp2cb Rattus norvegicus Rattus norvegicus
Full name:
protein phosphatase 2 catalytic subunit beta
Synonyms:
Pp2a2, serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, PP2A-beta, protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform, protein phosphatase 2, catalytic subunit, beta isoform, protein phosphatase 2, catalytic subunit, beta isozyme, protein phosphatase 2A catalytic alpha subunit, protein phosphatase 2a, catalytic subunit, beta isoform, protein phosphatase-2A-beta
Genomic Location:
Chr 16: 62330513-62351968
Description:
catalytic subunit of multimeric serine/threonine phosphatase; involved in insulin signal transduction; negatively regulates the Ras/MAP kinase pathway by binding to Shc, inhibiting tyrosine phosphorylation
Orthologs:
Homo sapiens Mus musculus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Danio rerio Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_017040
XM_001067962
Protein Names
P62716
Q6LDK0



GO Molecular Function

protein serine/threonine phosphatase activity | cation binding | phosphatase activity | hydrolase activity | catalytic activity | phosphoprotein phosphatase activity | hydrolase activity, acting on ester bonds | protein heterodimerization activity | ion binding | protein binding | protein dimerization activity | phosphoric ester hydrolase activity | metal ion binding | protein C-terminus binding

GO Biological Process

protein serine/threonine phosphatase activity | response to endoplasmic reticulum stress | protein dephosphorylation | positive regulation of microtubule binding | proteolysis | negative regulation of cellular process | response to metal ion | response to drug | response to antibiotic | cellular process | organic substance catabolic process | proteolysis involved in cellular protein catabolic process | negative regulation of signaling | response to inorganic substance | regulation of binding | response to hydrogen peroxide | regulation of cellular process | regulation of metabolic process | catabolic process | cellular component organization | positive regulation of protein binding | phosphatase activity | response to stimulus | response to stress | programmed cell death | cellular protein catabolic process | proteasomal protein catabolic process | apoptotic mitochondrial changes | protein modification process | mitochondrion organization | macromolecule modification | apoptotic process | nitrogen compound metabolic process | regulation of signal transduction | phosphorus metabolic process | regulation of small GTPase mediated signal transduction | regulation of gene expression | cellular response to stress | protein catabolic process | phosphoprotein phosphatase activity | response to oxidative stress | response to toxic substance | phosphate-containing compound metabolic process | regulation of microtubule binding | proteasome-mediated ubiquitin-dependent protein catabolic process | positive regulation of molecular function | protein metabolic process | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | metabolic process | organic substance metabolic process | cell death | response to reactive oxygen species | negative regulation of small GTPase mediated signal transduction | negative regulation of Ras protein signal transduction | positive regulation of binding | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | regulation of cell communication | dephosphorylation | negative regulation of signal transduction | regulation of protein binding | cellular protein metabolic process | regulation of Ras protein signal transduction | organelle organization | cellular protein modification process | response to lead ion | cellular metabolic process | modification-dependent protein catabolic process | regulation of signaling | macromolecule metabolic process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | catalytic complex | chromosome, centromeric region | cell | cytoplasm | spindle | intracellular organelle | protein-containing complex | microtubule cytoskeleton | protein phosphatase type 2A complex | spindle pole | protein serine/threonine phosphatase complex | membrane-bounded organelle | nucleus | organelle | cytoskeleton | intracellular