QuickView for YES1 (gene)
- Gene Symbol:
- YES1
Homo sapiens - Full name:
- YES proto-oncogene 1, Src family tyrosine kinase
- Synonyms:
- HsT441, P61-YES, Yes, c-yes, tyrosine-protein kinase Yes, YES1 proto-oncogene, Src family tyrosine kinase, Yamaguchi sarcoma oncogene, cellular yes-1 protein, proto-oncogene c-Yes, proto-oncogene tyrosine-protein kinase YES, v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
- Genomic Location:
- Chr 18: 711592-802327
- Description:
-
This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Danio rerio , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-1 , Predicted Gene Targets for miR-125 , Predicted Gene Targets for miR-133 , Predicted Gene Targets for miR-145 , Predicted Gene Targets for miR-183 , Predicted Gene Targets for miR-20 , Predicted Gene Targets for miR-205 , Predicted Gene Targets for miR-208 , Predicted Gene Targets for miR-23 , Predicted Gene Targets for miR-26
- Cytogenetic Map:
-
18p11.32
| Transcripts Names |
|---|
| NM_005433 |
| XM_024451246 |
| XM_024451244 |
| XM_024451245 |
| XM_005258139 |
| XM_024451247 |
| XM_024451243 |
| XM_017025960 |
GO Molecular Function
protein phosphorylated amino acid binding | enzyme binding | phosphotyrosine residue binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | catalytic activity | ion channel binding | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | phosphoprotein binding | protein tyrosine kinase activity | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | epidermal growth factor receptor binding | non-membrane spanning protein tyrosine kinase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | growth factor receptor binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
positive regulation of immune response | positive regulation of macromolecule biosynthetic process | cell motility | immune response-regulating signaling pathway | cellular response to platelet-derived growth factor stimulus | regulation of localization | positive regulation of peptidyl-tyrosine phosphorylation | peptidyl-amino acid modification | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | positive regulation of lymphocyte activation | cell differentiation | immune response-activating cell surface receptor signaling pathway | lymphocyte costimulation | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | positive regulation of cellular biosynthetic process | cellular process | Fc-gamma receptor signaling pathway involved in phagocytosis | localization | response to growth factor | positive regulation of nitrogen compound metabolic process | cellular response to retinoic acid | peptidyl-tyrosine autophosphorylation | regulation of immune response | regulation of cellular process | cellular response to lipid | regulation of metabolic process | positive regulation of cellular protein metabolic process | ephrin receptor signaling pathway | response to transforming growth factor beta | response to stimulus | regulation of peptidyl-tyrosine phosphorylation | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of cell-cell adhesion | positive regulation of cell activation | positive regulation of T cell activation | immune response-activating signal transduction | blood circulation | positive regulation of RNA biosynthetic process | protein modification process | regulation of cell adhesion | macromolecule modification | leukocyte migration | regulation of nucleic acid-templated transcription | locomotion | nitrogen compound metabolic process | cell migration | phosphorus metabolic process | regulation of phosphorylation | Fc-gamma receptor signaling pathway | regulation of T cell activation | regulation of gene expression | response to lipid | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | protein autophosphorylation | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | regulation of vascular permeability | vesicle-mediated transport | regulation of transcription by RNA polymerase II | response to platelet-derived growth factor | regulation of cellular protein metabolic process | phosphorylation | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | regulation of protein phosphorylation | regulation of RNA metabolic process | response to retinoic acid | protein tyrosine kinase activity | cellular response to transforming growth factor beta stimulus | activation of immune response | protein metabolic process | positive regulation of protein modification process | response to organic substance | import into cell | cell surface receptor signaling pathway | metabolic process | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | endocytosis | protein kinase activity | organic substance metabolic process | regulation of glucose transmembrane transport | regulation of cell activation | regulation of phosphate metabolic process | T cell costimulation | non-membrane spanning protein tyrosine kinase activity | signaling | regulation of transcription, DNA-templated | positive regulation of phosphorylation | cellular protein metabolic process | kinase activity | developmental process | Fc receptor signaling pathway | cellular protein modification process | Fc receptor mediated stimulatory signaling pathway | regulation of transport | positive regulation of transcription, DNA-templated | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | immune system process | cellular metabolic process | cellular response to organic substance | phagocytosis | positive regulation of leukocyte cell-cell adhesion | signal transduction | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
supramolecular fiber | cytoplasmic side of plasma membrane | intracellular membrane-bounded organelle | extrinsic component of membrane | adherens junction | microtubule organizing center | focal adhesion | cell | cytoplasmic side of membrane | extrinsic component of plasma membrane | cytoplasm | cell-substrate junction | intracellular organelle | actin cytoskeleton | Golgi apparatus | endomembrane system | plasma membrane | extrinsic component of cytoplasmic side of plasma membrane | vesicle | extracellular exosome | microtubule cytoskeleton | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | cell-substrate adherens junction | cytosol | actin filament | cytoskeleton | intracellular | cell junction | membrane | supramolecular complex
