Name: | Yohimbine |
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PubChem Compound ID: | 120635 |
Description: | A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic in the treatment of ERECTILE DYSFUNCTION. |
Molecular formula: | C21H26N2O3 |
Molecular weight: | 354.443 g/mol |
Synonyms: |
Mesoyohimbine; Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16-beta,17-alpha,20-alpha)- (9CI); 131-03-3; Isoyohimbine; Corynanthidine; alpha-Yohimbine; EINECS 205-006-9; Rauwolscine; Methyl (16beta,17alpha,20alpha)-17-hydroxyyohimban-16-carboxylate; 17-alpha-Hydroxy-20-alpha-yohimban-16-beta-carboxylic acid methyl ester.
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Name: | Yohimbine |
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Name (isomeric): | DB01392 |
Drug Type: | small molecule |
Description: | A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic in the treatment of ERECTILE DYSFUNCTION. |
Synonyms: |
Yohimbin
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Brand: | Yovital, Yohimar, Baron-X, Thybine, Dayto himbin, Yoman, Yohimex, Aphrodyne, Yocon, Actibine |
Category: | Mydriatics, Adrenergic alpha-Antagonists |
CAS number: | 146-48-5 |
Indication: | Indicated as a sympatholytic and mydriatic. Impotence has been successfully treated with yohimbine in male patients with vascular or diabetic origins and psychogenic origins. |
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Pharmacology: |
Yohimbine is an indolalkylamine alkaloid with chemical similarity to reserpine. Yohimbine blocks presynaptic alpha-2 adrenergic receptors. Its action on peripheral blood vessels resembles that of reserpine, though it is weaker and of short duration. Yohimbine's peripheral autonomic nervous system effect is to increase parasympathetic (cholinergic) ...
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Mechanism of Action: |
Yohimbine is a pre-synaptic alpha 2-adrenergic blocking agent. The exact mechanism for its use in impotence has not been fully elucidated. However, yohimbine may exert its beneficial effect on erectile ability through blockade of central alpha 2-adrenergic receptors producing an increase in sympathetic drive secondary to an increase in norepinephri...
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Absorption: | Rapidly absorbed following oral administration. Bioavailability is highly variable, ranging from 7 to 87% (mean 33%). |
Biotransformation: | Yohimbine appears to undergo extensive metabolism in an organ of high flow such as the liver or kidney, however, the precise metabolic fate of yohimbine has not been fully determined. |
Half Life: | Elimination half-life is approximately 36 minutes. |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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