QuickView for ZAKI-4 (gene)

Gene Symbol:

RCAN2 Homo sapiens

Full name:

regulator of calcineurin 2

Synonyms:

CSP2, DSCR1L1, MCIP2, RCN2, ZAKI-4, ZAKI4, calcipressin-2, Down syndrome candidate region 1-like 1, Down syndrome critical region gene 1-like 1, myocyte-enriched calcineurin-interacting protein 2, thyroid hormone-responsive (skin fibroblasts), thyroid hormone-responsive protein ZAKI-4

Genomic Location:

Chr 6: 46296428-46401490

Description:

This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyr...

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This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  MYOD_Q6_01 ,  AP1_C ,  TGANTCA_AP1_C ,  TAL1ALPHAE47_01 ,  RYTTCCTG_ETS2_B ,  HOXA4_Q2 ,  AP1_Q6 ,  AGGAGTG_MIR483 ,  TGACCTY_ERR1_Q2 ,  ACTGTGA_MIR27A_MIR27B ,  CTTTGTA_MIR524 ,  TGAYRTCA_ATF3_Q6 ,  TATCTGG_MIR488 ,  NFE2_01 ,  AP1_Q6_01 ,  TAL1BETAE47_01 ,  ACATTCC_MIR1_MIR206 ,  CACCAGC_MIR138 ,  OCT1_03 ,  GFI1_01 ,  MYB_Q6 ,  TAL1BETAITF2_01 ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN ,  TGACCTTG_SF1_Q6 ,  HNF6_Q6

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Cytogenetic Map:

6p12.3

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