QuickView for ZEB1 (gene)

Gene Symbol:

ZEB1 Homo sapiens

Full name:

zinc finger E-box binding homeobox 1

Synonyms:

AREB6, BZP, DELTAEF1, FECD6, NIL2A, PPCD3, TCF8, ZFHEP, ZFHX1A, zinc finger E-box-binding homeobox 1, delta-crystallin enhancer binding factor 1, negative regulator of IL2, posterior polymorphous corneal dystrophy 3, transcription factor 8 (represses interleukin 2 expression), zinc finger homeodomain enhancer-binding protein

Genomic Location:

Chr 10: 31648148-31856742

Description:

This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different iso...

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This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GTATTAT_MIR3693P ,  CEBPA_01 ,  GATA1_03 ,  TTANTCA_UNKNOWN ,  MZF1_01 ,  MAZ_Q6 ,  SRF_Q6 ,  CTACTGT_MIR199A ,  GCANCTGNY_MYOD_Q6 ,  TAAYNRNNTCC_UNKNOWN ,  NFKAPPAB65_01 ,  GGGAGGRR_MAZ_Q6 ,  GGGYGTGNY_UNKNOWN ,  CAGGTA_AREB6_01 ,  E2F1_Q6_01 ,  CAGGTG_E12_Q6 ,  AP4_01 ,  ZID_01 ,  RRAGTTGT_UNKNOWN ,  AHR_Q5 ,  OCT1_06 ,  YCATTAA_UNKNOWN ,  AREB6_03 ,  AATGTGA_MIR23A_MIR23B ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  IK2_01 ,  WTTGKCTG_UNKNOWN ,  IK3_01 ,  IK1_01 ,  CREL_01 ,  AACTTT_UNKNOWN ,  MZF1_02 ,  RRCCGTTA_UNKNOWN ,  STTTCRNTTT_IRF_Q6 ,  ETF_Q6 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: miRecords):

hsa-miR-200a Targeted Genes ,  hsa-miR-200b Targeted Genes ,  hsa-miR-205 Targeted Genes ,  [miR-200] Targeted Genes ,  hsa-miR-200c Targeted Genes

Cytogenetic Map:

10p11.22

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