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QuickView for ZFPM2;jsessionid=DF3FB09F3D48514796170E68146687DE (gene)


Gene Symbol:
ZFPM2 Homo sapiens Homo sapiens
Full name:
zinc finger protein, FOG family member 2
Synonyms:
DIH3, FOG2, SRXY9, ZC2HC11B, ZNF89B, hFOG-2, zinc finger protein ZFPM2, FOG-2, Friend of GATA2, friend of GATA 2, friend of GATA protein 2, transcription factor GATA4, modulator of, zinc finger protein 89B, zinc finger protein, multitype 2
Genomic Location:
Chr 8: 106400323-106885943
Description:
The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The family members modulate the activity of GATA family proteins, which are important regulators of hematopoiesis and cardiogenesis in mammals. It has been demonstrated that the protein can both activate and down-regulate expression...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
CTTGTAT_MIR381 POU6F1_01 PBX1_02 GTATTAT_MIR3693P GTGCCAT_MIR183 TTTGCAC_MIR19A_MIR19B GATA1_03 HNF1_01 TTANTCA_UNKNOWN OCT1_04
miRNA binding sites
(Source: TargetScan):
Predicted Gene Targets for miR-103 Predicted Gene Targets for miR-130 Predicted Gene Targets for miR-134 Predicted Gene Targets for miR-138 Predicted Gene Targets for miR-142-5p Predicted Gene Targets for miR-145 Predicted Gene Targets for miR-148 Predicted Gene Targets for miR-153 Predicted Gene Targets for miR-183 Predicted Gene Targets for miR-19
Cytogenetic Map:
chr 8
8q23.1





GO Molecular Function

RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | cation binding | nucleic acid binding | DNA binding | transcription corepressor activity | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | ion binding | organic cyclic compound binding | transcription coactivator activity | protein binding | zinc ion binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | transition metal ion binding | transcription coregulator activity | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | ventricular cardiac muscle tissue morphogenesis | positive regulation of macromolecule biosynthetic process | negative regulation of female gonad development | developmental process involved in reproduction | muscle tissue development | positive regulation of striated muscle tissue development | gonad development | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | regulation of heart growth | cell differentiation | respiratory tube development | negative regulation of fat cell differentiation | positive regulation of gonad development | mesenchyme development | blood vessel morphogenesis | regulation of cardiac muscle cell proliferation | positive regulation of cellular biosynthetic process | cellular process | heart morphogenesis | reproductive system development | mesoderm development | negative regulation of nucleic acid-templated transcription | regulation of striated muscle tissue development | hemostasis | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of fat cell differentiation | regulation of cell differentiation | muscle structure development | ventricular septum morphogenesis | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | development of primary sexual characteristics | muscle organ morphogenesis | response to stimulus | cardiac right ventricle morphogenesis | vasculature development | respiratory system development | response to stress | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | tube morphogenesis | cardiac muscle tissue development | muscle tissue morphogenesis | reproduction | cardiovascular system development | cardiac ventricle morphogenesis | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | embryo development | blood vessel development | blood coagulation | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | reproductive process | multicellular organism development | positive regulation of muscle organ development | wound healing | regulation of gene expression | regulation of female gonad development | outflow tract morphogenesis | positive regulation of male gonad development | positive regulation of cellular metabolic process | animal organ morphogenesis | regulation of nitrogen compound metabolic process | transcription corepressor activity | regulation of transcription by RNA polymerase II | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | biosynthetic process | positive regulation of cardiac muscle cell proliferation | regulation of male gonad development | aromatic compound biosynthetic process | cardiac septum morphogenesis | chordate embryonic development | striated muscle tissue development | cardiac muscle tissue morphogenesis | regulation of cellular metabolic process | vasculogenesis | heart development | positive regulation of cell proliferation | embryo development ending in birth or egg hatching | transcription coactivator activity | regulation of RNA metabolic process | coagulation | positive regulation of organ growth | ventricular septum development | DNA-binding transcription factor activity | cardiac ventricle development | regulation of growth | regulation of cardiac muscle tissue development | tissue morphogenesis | response to wounding | ventricular cardiac muscle tissue development | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of transcription, DNA-templated | embryonic organ development | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | gene expression | positive regulation of muscle tissue development | transcription, DNA-templated | gonadal mesoderm development | lung development | positive regulation of developmental growth | positive regulation of growth | regulation of transcription, DNA-templated | regulation of developmental growth | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of organ growth | reproductive structure development | regulation of developmental process | developmental process | cardiac septum development | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of heart growth | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | cardiac chamber development | heterocycle metabolic process | in utero embryonic development | positive regulation of metabolic process | cellular metabolic process | regulation of cell death | sex differentiation | positive regulation of cardiac muscle tissue development | right ventricular cardiac muscle tissue morphogenesis | negative regulation of cell death | circulatory system development | negative regulation of cell differentiation | muscle organ development | positive regulation of gene expression | outflow tract septum morphogenesis | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular