QuickView for ZPKP1 (gene)
- Gene Symbol:
- MAP3K12
Homo sapiens - Full name:
- mitogen-activated protein kinase kinase kinase 12
- Synonyms:
- DLK, MEKK12, MUK, ZPK, ZPKP1, mitogen-activated protein kinase kinase kinase 12, MAPK-upstream kinase, dual leucine zipper bearing kinase, dual leucine zipper kinase DLK, leucine zipper protein kinase, mixed lineage kinase, protein kinase MUK
- Genomic Location:
- Chr 12: 52160547-52179538
- Description:
-
This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipp...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Pan troglodytes , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-122a , Predicted Gene Targets for miR-130 , Predicted Gene Targets for miR-150 , Predicted Gene Targets for miR-19 , Predicted Gene Targets for miR-191 , Predicted Gene Targets for miR-20 , Predicted Gene Targets for miR-22 , Predicted Gene Targets for miR-27 , Predicted Gene Targets for miR-30 , Predicted Gene Targets for miR-539
- Cytogenetic Map:
-
12q13.13
| Transcripts Names |
|---|
| NM_006301 |
| NM_001193511 |
| XM_005269138 |
| XM_011538725 |
| XM_017019956 |
| XM_005269140 |
| XM_006719588 |
GO Molecular Function
kinase binding | protein kinase binding | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | MAP kinase kinase kinase activity | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | JUN kinase kinase kinase activity | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding
GO Biological Process
regulation of JUN kinase activity | intracellular signal transduction | regulation of programmed cell death | peptidyl-amino acid modification | negative regulation of neuron death | negative regulation of cellular process | regulation of MAP kinase activity | histone modification | positive regulation of phosphate metabolic process | regulation of neuron death | cellular process | chromatin organization | positive regulation of protein kinase activity | negative regulation of apoptotic process | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | positive regulation of cellular protein metabolic process | cellular component organization | MAPK cascade | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | peptidyl-threonine phosphorylation | JNK cascade | positive regulation of protein metabolic process | signal transduction by protein phosphorylation | response to stress | protein serine/threonine kinase activity | positive regulation of protein serine/threonine kinase activity | protein modification process | macromolecule modification | activation of protein kinase activity | stress-activated protein kinase signaling cascade | regulation of cellular response to stress | negative regulation of neuron apoptotic process | nitrogen compound metabolic process | regulation of signal transduction | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of motor neuron apoptotic process | cellular response to stress | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | MAP kinase kinase kinase activity | protein autophosphorylation | regulation of nitrogen compound metabolic process | positive regulation of JNK cascade | positive regulation of intracellular signal transduction | stress-activated MAPK cascade | regulation of cellular protein metabolic process | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | JUN kinase kinase kinase activity | regulation of neuron apoptotic process | activation of MAPKK activity | activation of JNKK activity | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | histone phosphorylation | negative regulation of motor neuron apoptotic process | positive regulation of molecular function | activation of MAPK activity | protein metabolic process | positive regulation of protein modification process | regulation of kinase activity | regulation of intracellular signal transduction | metabolic process | negative regulation of programmed cell death | protein kinase activity | organic substance metabolic process | positive regulation of kinase activity | regulation of phosphate metabolic process | regulation of JNK cascade | positive regulation of MAPK cascade | regulation of stress-activated MAPK cascade | regulation of cell communication | signaling | covalent chromatin modification | positive regulation of phosphorylation | cellular protein metabolic process | positive regulation of MAP kinase activity | kinase activity | organelle organization | peptidyl-serine phosphorylation | cellular protein modification process | positive regulation of JUN kinase activity | positive regulation of metabolic process | chromosome organization | cellular metabolic process | regulation of cell death | activation of JUN kinase activity | negative regulation of cell death | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
neuron projection | cell | distal axon | cytoplasm | cell projection | plasma membrane | site of polarized growth | cell periphery | axon | growth cone | cytosol | intracellular | membrane
