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QuickView for ZW10 (gene)


Gene Symbol:
ZW10 Homo sapiens Homo sapiens
Full name:
zw10 kinetochore protein
Synonyms:
HZW10, KNTC1AP, centromere/kinetochore protein zw10 homolog, ZW10 homolog, centromere/kinetochore protein, ZW10, kinetochore associated, homolog, zeste white 10 homolog
Genomic Location:
Chr 11: 113109119-113149635
Description:
This gene encodes a protein that is one of many involved in mechanisms to ensure proper chromosome segregation during cell division. This protein is an essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 11
11q23.2


Transcripts Names
NM_004724
XM_017018558
XM_017018559
Protein Names
O43264
A1A528



GO Molecular Function

sequence-specific DNA binding | nucleic acid binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | protein binding | double-stranded DNA binding | centromeric DNA binding | heterocyclic compound binding

GO Biological Process

regulation of cell cycle process | microtubule cytoskeleton organization involved in mitosis | establishment of localization | negative regulation of cellular process | microtubule cytoskeleton organization | establishment of mitotic spindle orientation | regulation of organelle organization | intracellular transport | microtubule-based process | regulation of chromosome segregation | cellular process | establishment of organelle localization | localization | protein transport | regulation of exit from mitosis | protein localization to kinetochore | regulation of mitotic nuclear division | regulation of chromosome separation | macromolecule localization | negative regulation of chromosome segregation | endomembrane system organization | regulation of cell cycle | establishment of mitotic spindle localization | establishment of localization in cell | negative regulation of mitotic metaphase/anaphase transition | spindle checkpoint | regulation of cellular process | organelle localization | establishment of cell polarity | cellular component organization | establishment of chromosome localization | regulation of mitotic cell cycle phase transition | chromosome segregation | establishment of spindle localization | regulation of cell cycle phase transition | reproduction | cellular localization | cellular component assembly | reproductive process | negative regulation of mitotic cell cycle phase transition | retrograde vesicle-mediated transport, Golgi to ER | sister chromatid segregation | spindle localization | organic substance transport | cell cycle | mitotic metaphase plate congression | regulation of mitotic sister chromatid separation | peptide transport | vesicle-mediated transport | protein localization to organelle | negative regulation of mitotic nuclear division | establishment of spindle orientation | cell division | metaphase plate congression | mitotic spindle assembly checkpoint | establishment or maintenance of cell polarity | nuclear chromosome segregation | negative regulation of mitotic sister chromatid segregation | negative regulation of mitotic sister chromatid separation | Golgi vesicle transport | regulation of mitotic cell cycle | protein-containing complex assembly | Golgi organization | protein localization to chromosome, centromeric region | regulation of sister chromatid segregation | mitotic cell cycle | nuclear division | negative regulation of mitotic cell cycle | cellular protein localization | amide transport | cytoskeleton organization | regulation of chromosome organization | mitotic nuclear division | establishment of protein localization | negative regulation of cell cycle | regulation of mitotic sister chromatid segregation | meiotic cell cycle | negative regulation of chromosome organization | ER to Golgi vesicle-mediated transport | protein localization | cellular macromolecule localization | organelle organization | regulation of mitotic metaphase/anaphase transition | chromosome organization | mitotic cell cycle checkpoint | negative regulation of cell cycle process | cell cycle checkpoint | mitotic sister chromatid segregation | regulation of cellular component organization | protein localization to chromosome

GO Cellular Component

supramolecular fiber | chromosome | intracellular membrane-bounded organelle | chromosome, centromeric region | condensed chromosome, centromeric region | cell | kinetochore | tethering complex | microtubule | cytoplasm | spindle | Dsl1/NZR complex | intracellular organelle | endoplasmic reticulum | kinetochore microtubule | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | condensed chromosome kinetochore | RZZ complex | microtubule cytoskeleton | spindle pole | spindle microtubule | membrane-bounded organelle | nucleus | organelle | cytosol | cytoskeleton | intracellular | membrane | supramolecular complex | condensed chromosome