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QuickView for Zap70 (gene)


Gene Symbol:
ZAP70 Homo sapiens Homo sapiens
Full name:
zeta chain of T cell receptor associated protein kinase 70
Synonyms:
ADMIO2, IMD48, SRK, STCD, STD, TZK, ZAP-70, tyrosine-protein kinase ZAP-70, 70 kDa zeta-associated protein, 70 kDa zeta-chain associated protein, syk-related tyrosine kinase, zeta chain of T cell receptor associated protein kinase 70kDa, zeta-chain (TCR) associated protein kinase 70kDa, zeta-chain associated protein kinase, 70kD
Genomic Location:
Chr 2: 97696463-97722755
Description:
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src fami...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Canis lupus familiaris Gallus gallus Pan troglodytes Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 2
2q11.2





GO Molecular Function

protein phosphorylated amino acid binding | phosphotyrosine residue binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | phosphoprotein binding | protein tyrosine kinase activity | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | non-membrane spanning protein tyrosine kinase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | small molecule binding

GO Biological Process

positive regulation of immune response | adaptive immune response | cell motility | immune response-regulating signaling pathway | intracellular signal transduction | peptidyl-amino acid modification | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | positive regulation of developmental process | positive regulation of lymphocyte activation | cell differentiation | immune response-activating cell surface receptor signaling pathway | regulation of T cell differentiation | T cell receptor signaling pathway | positive regulation of cell adhesion | peptidyl-tyrosine phosphorylation | negative T cell selection | positive regulation of T cell differentiation | cellular process | lymphocyte differentiation | localization | regulation of calcium-mediated signaling | immune system development | regulation of cell differentiation | regulation of immune response | regulation of cellular process | leukocyte activation | negative thymic T cell selection | T cell activation | response to stimulus | positive regulation of immune system process | leukocyte aggregation | positive regulation of lymphocyte proliferation | regulation of cell proliferation | positive regulation of cell-cell adhesion | positive regulation of cell activation | positive regulation of T cell activation | immune response-activating signal transduction | hemopoiesis | protein modification process | regulation of cell adhesion | macromolecule modification | regulation of lymphocyte differentiation | leukocyte migration | leukocyte differentiation | locomotion | positive regulation of mononuclear cell proliferation | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | cell migration | positive regulation of lymphocyte differentiation | phosphorus metabolic process | regulation of T cell activation | positive regulation of alpha-beta T cell differentiation | positive thymic T cell selection | positive regulation of alpha-beta T cell proliferation | regulation of lymphocyte activation | lymphocyte migration | positive regulation of intracellular signal transduction | alpha-beta T cell differentiation | positive regulation of cell differentiation | positive regulation of calcium-mediated signaling | lymphocyte aggregation | B cell activation | positive regulation of T cell proliferation | phosphorylation | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of alpha-beta T cell differentiation | positive regulation of signal transduction | positive regulation of cell proliferation | lymphocyte activation | protein tyrosine kinase activity | T cell differentiation | activation of immune response | protein metabolic process | T cell selection | T cell differentiation in thymus | regulation of hemopoiesis | regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | leukocyte cell-cell adhesion | metabolic process | positive regulation of leukocyte activation | positive T cell selection | cell adhesion | immune response | protein kinase activity | thymic T cell selection | organic substance metabolic process | beta selection | animal organ development | regulation of cell activation | alpha-beta T cell activation | antigen receptor-mediated signaling pathway | cell-cell adhesion | cell activation | non-membrane spanning protein tyrosine kinase activity | regulation of cell communication | signaling | regulation of T cell proliferation | cellular protein metabolic process | T cell aggregation | regulation of developmental process | kinase activity | developmental process | positive regulation of alpha-beta T cell activation | cellular protein modification process | regulation of cell-cell adhesion | T cell migration | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | positive regulation of leukocyte cell-cell adhesion | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

immunological synapse | T cell receptor complex | cell | plasma membrane protein complex | cytoplasm | receptor complex | membrane microdomain | cell-cell junction | protein-containing complex | plasma membrane | membrane raft | cell periphery | cytosol | intracellular | cell junction | membrane