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QuickView for acamprosate (compound)
PubChem
| Name: | acamprosate |
|---|---|
| PubChem Compound ID: | 155434 |
| Molecular formula: | C10H20CaN2O8S2 |
| Molecular weight: | 400.484 g/mol |
| Synonyms: |
Campral; 77337-76-9; Acamprosate calcium; Calcium(2+) 3-(acetylamino)propanesulphonate; D02780; 1-Propanesulfonic acid, 3-(acetylamino)-, calcium salt (2:1); LS-120941; Alcomed; Campral EC; Sobriol.
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DrugBank
Identification
| Name: | acamprosate |
|---|---|
| Name (isomeric): | DB00659 |
| Drug Type: | small molecule |
| Synonyms: |
N-Acetylhomotaurine; 3-Acetamido-1-propanesulfonic acid; 3-(Acetylamino)propanesulphonic acid
|
| Brand: | Campral |
| Category: | Alcohol Deterrents |
| CAS number: | 77337-76-9 |
Pharmacology
| Indication: | For the maintenance of abstinence from alcohol in patients with alcohol dependence who are abstinent at treatment initiation |
|---|---|
| Pharmacology: |
Pharmacodynamic studies have shown that acamprosate calcium reduces alcohol intake in alcohol-dependent animals in a dose-dependent manner and that this effect appears to be specific to alcohol and the mechanisms of alcohol dependence. Acamprosate calcium has negligible observable central nervous system (CNS) activity in animals outside of its effe...
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| Mechanism of Action: |
The mechanism of action of acamprosate in maintenance of alcohol abstinence is not completely understood. Chronic alcohol exposure is hypothesized to alter the normal balance between neuronal excitation and inhibition. in vitro and in vivo studies in animals have provided evidence to suggest acamprosate may interact with glutamate and...
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| Absorption: | The absolute bioavailability of acamprosate after oral administration is about 11%. The food effect on absorption is not clinically significant and no adjustment of dose is necessary. |
| Protein binding: | Non detectable |
| Biotransformation: | Acamprosate does not undergo metabolism. |
| Route of elimination: | Following oral administration of CAMPRAL®, the major route of excretion is via the kidneys as acamprosate. |
| Half Life: | 20 - 33 hours |
| Toxicity: | In all reported cases of acute overdosage with acamprosate (total reported doses of up to 56 grams of acamprosate calcium), the only symptom that could be reasonably associated with acamprosate was diarrhea. |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
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Targets
