QuickView for acetylcysteine (compound)

(2R)-2-Acetamido-3-sulfanyl-propanoic acid; Broncholysin; 63664-54-0; Acetylcysteine; L-Cysteine, N-acetyl- & Tumor necrosis factor; Acetadote; Flumucetin; Spectrum3_000287; Spectrum2_000086; Acetein.
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(2R)-2-Acetamido-3-sulfanyl-propanoic acid; Broncholysin; 63664-54-0; Acetylcysteine; L-Cysteine, N-acetyl- & Tumor necrosis factor; Acetadote; Flumucetin; Spectrum3_000287; Spectrum2_000086; Acetein; EINECS 210-498-3; L-Cysteine, N-acetyl-; SMR000058377; KBioGR_000554; NSC-111180; Naxid; L-alpha-Acetamido-beta-mercaptopropionic acid; Mucolytikum Lappe; CHEBI:28939; 19542-74-6; (2S)-2-acetylamino-3-sulfanylpropanoic acid; Mucolator; Mucret; Fluprowit; N-Acetyl-3-mercaptoalanine; InChI=1/C5H9NO3S/c1-3(7)6-4(2-10)5(8)9/h4,10H,2H2,1H3,(H,6,7)(H,8,9; 616-91-1; 18829-79-3; N-Acetyl-S-glyceroylcysteine; Mercapturic acid, (R)-; NAC-TB; nchembio821-comp15; Mucolyticum; L-Cysteine, N-acetyl-, (3aS-(3aalpha,4beta,6aalpha))-; Mucosil; cysteine, N-acetyl-; Parvolex; Tixair; Exomuc; SPBio_000012; Fluimucil; NASGC; Acetilcisteina [INN-Spanish]; EU-0100081; N-Acetyl-L-cysteine & Tumor necrosis factor (TNF); Lysomucil; N-Acetyl-L-cysteine; Mucolyticum-Lappe; CCRIS 3764; Respaire; Acetylcysteine [USAN:BAN:INN]; L-Acetylcysteine; Mercapturic acid; Airbron; AIDS072180; AIDS-000468; Spectrum4_000137; DRG-0100; RK-0202; N-Acetylcysteine; NSC111180; NSC 111180; MLS000028419; Inspir; component of Naxid; Fluimucetin; 91918-35-3; AIDS-072180; N-Acetyl cysteine; NAC & TNF; (R)-2-acetylamino-3-mercaptopropanoic acid; Mucosolvin; Fabrol; Fluimicil Infantil; NAC; Mucolyticum Lappe; Acetylcysteinum [INN-Latin]; Mucomyst; HSDB 3003; Cysteine, N-acetyl-, L-; Fluatox; 7696-05-1; Brunac; 308079-78-9; KBio3_001294; Mucofilin; AIDS000468
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NAC; N-acetylcysteine

Acetylcysteine has been shown to reduce the extent of liver injury following acetaminophen overdose. It is most effective when given early, with benefit seen principally in patients treated within 8-10 hours of the overdose. Acetylcysteine likely protects the liver by maintaining or restoring the glutathione levels, or by acting as an alternate sub...
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Acetylcysteine has been shown to reduce the extent of liver injury following acetaminophen overdose. It is most effective when given early, with benefit seen principally in patients treated within 8-10 hours of the overdose. Acetylcysteine likely protects the liver by maintaining or restoring the glutathione levels, or by acting as an alternate substrate for conjugation with, and thus detoxification of, the reactive metabolite.
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Acetylcysteine may protect against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione. It does this by producing the glutathione precursor cysteine. Glutathione is required to inactivate an intermediate metabolite (N-acetyl-p-benzoquinoneimine) of acetaminophen that is thought to be hepat...
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Acetylcysteine may protect against acetaminophen overdose-induced hepatotoxicity by maintaining or restoring hepatic concentrations of glutathione. It does this by producing the glutathione precursor cysteine. Glutathione is required to inactivate an intermediate metabolite (N-acetyl-p-benzoquinoneimine) of acetaminophen that is thought to be hepatotoxic. In acetaminophen overdose, excessive quantities of this metabolite are formed because the primary metabolic (glucuronide and sulfate conjugation) pathways become saturated. Acetylcysteine may act by reducing the metabolite to the parent compound and/or by providing sulfhydryl for conjugation of the metabolite. Experimental evidence also suggests that a sulfhydryl-containing compound such as acetylcysteine may also directly inactivate the metabolite. When inhaled, cetylcysteine exerts its mucolytic action through its free sulfhydryl group, which opens the disulfide bonds and lowers mucus viscosity. This action increases with increasing pH and is most significant at pH 7 to 9. The mucolytic action of acetylcysteine is not affected by the presence of DNA. Acetylcysteine is also an antioxidant and reduces oxidative stress.
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