Name: | Acetylglucosamine |
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PubChem Compound ID: | 1738118 |
Description: | The N-acetyl derivative of glucosamine. |
Molecular formula: | C8H15NO6 |
Molecular weight: | 221.208 g/mol |
Synonyms: |
2-Acetamido-2-deoxy-D-glucose; CHEBI:17411; N-Acetylchitosamine; N-Acetyl-D-glucosamine; D-GlcNAc; ZINC02077807
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Name: | Acetylglucosamine |
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Name (isomeric): | DB00141 |
Drug Type: | small molecule |
Description: | The N-acetyl derivative of glucosamine. |
Synonyms: |
NAG; 2-Acetamido-2-deoxy-D-glucose; N-Acetylchitosamine; GlcNAc; Glucosamine Complex
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Brand: | Maxi GS, GS-500, Aflexa, Natures Blend Glucosamine |
Category: | Micronutrient, Dietary supplement |
CAS number: | 7512-17-6 |
Indication: | For the treatment and prevention of osteoarthritis, by itself or in combination with chondroitin sulfate. |
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Mechanism of Action: |
The mechanism of action in relieving arthritic pain and in repair of cartilage is a matter of speculation. Biochemically, glucosamine is involved in glycoprotein metabolism. Glycoproteins, known as proteoglycans, form the ground substance in the extra-cellular matrix of connective tissue. Proteoglycans are polyanionic substances of high-molecular w...
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Absorption: | Approximately 90% of orally administered glucosamine (salt form) gets absorbed from the small intestine. |
Biotransformation: | A significant fraction of ingested glucosamine is catabolized by first-pass metabolism in the liver. |
Toxicity: | Mouse, intravenous LD50 is 4170 mg/kg. Side effects that have been reported are mainly mild gastrointestinal complaints such as heartburn, epigastric distress and diarrhea. No allergic reactions have been reported including sulfa-allergic reactions to glucosamine sulfate. |
Affected organisms: | Humans and other mammals |