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QuickView for acid, citric (compound)
PubChem
| Name: | Citric Acid |
|---|---|
| PubChem Compound ID: | 311 |
| Description: | A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability. |
| Molecular formula: | C6H8O7 |
| Molecular weight: | 192.124 g/mol |
| Synonyms: |
Suby G; Lead citrate (Pb3(C6H5O7)2); NSC 30279; 3-Carboxy-3-hydroxypentane-1,5-dioic acid; H3cit; Spectrum3_001850; Kyselina 2-hydroxy-1,2,3-propantrikarbonova [Czech]; D00037; NCIOpen2_004062; Citric acid, anhydrous (USP).
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Suby G; Lead citrate (Pb3(C6H5O7)2); NSC 30279; 3-Carboxy-3-hydroxypentane-1,5-dioic acid; H3cit; Spectrum3_001850; Kyselina 2-hydroxy-1,2,3-propantrikarbonova [Czech]; D00037; NCIOpen2_004062; Citric acid, anhydrous (USP); 1,2,3-PROPANETRICARBOXYLIC ACID,2-HYDROXY (CITRIC ACID); NCIOpen2_004502; NCI60_022579; NSC83517; NSC626579; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, iron (3+) salt (1:1); Citric acid, nickel (2+) salt (2:3); NSC15011; 1,2, 3-Propanetricarboxylic acid, 2-hydroxy-, nickel (2+) salt (2:3); NCIStruc1_000057; FLC; C00158; Chromium citrate C6H5CrO7; 2-Hydroxy-1,2,3-propanetricarboxylic acid; BRN 0782061; EPA Pesticide Chemical Code 021801; Citrate Ion; citr; Citric acid hydrate; 3522-50-7; 245654-34-6; FEMA Number 2306; AI3-06286; Indium citrate; 1,2, 3-Propanetricarboxylic acid, 2-hydroxy-, lead (2+) salt (2:3); 3344-18-1; 2-Hydroxy-1,2, 3-propanetricarboxylic acid; AIDS017733; Citric acid; Lead citrate; 2-Hydroxytricarballylic acid; Uro-trainer; Citric acid, iron (3+) salt (1:1); Citric acid anhydrous; KBio3_002740; 12262-73-6; 2-Hydroxypropanetricarboxylic acid; NCIStruc2_000099; Caswell No. 221C; .beta.-Hydroxytricarballylic acid; 1,2,3-Propanetricarboxylic acid, 2-hydroxy- (9CI); Citric acid, gallium(II) salt; Citric acid, lead (2+) salt (2:3); Gallium citrate; Citrate; Hydrocerol A; K-Lyte DS; 4-03-00-01272 (Beilstein Handbook Reference); Citro; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, magnesium salt (2:3); InChI=1/C6H8O7/c7-3(8)1-6(13,5(11)12)2-4(9)10/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12; 4194-69-8; NSC7705; Ferric citrate; NSC 626579; NSC157503; Nickel citrate; NCGC00090954-01; Iron citrate, FeC6H5O7; Citric acid anhydrous (JAN); K-lyte; E 330; CIT; EINECS 201-069-1; F 0001 (polycarboxylic acid); 6018-92-4; Anhydrous citric acid; 77-92-9; 2-hydroxypropane-1,2,3-tricarboxylic acid; Trilead dicitrate; Aciletten; 27905-02-8; FEMA No. 2306; NSC112228; 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, indium (3+) salt (3:1); Magnesium citrate; NSC30279; NSC77165; NSC112226; NSC112227; Kyselina citronova [Czech]; AIDS-017733; Citric acid, anhydrous; CHEBI:30769; CITRIC ACID, GALLIUM SALT (1:1); 512-26-5; Magnesium citrate, Mg3(C6H5O7)2; 5077-53-2; Citric acid [USAN:JAN]; CCRIS 3292; Citric acid monohydrate; K-Lyte/Cl; LS-2418; 43136-35-2; Iron(III) citrate; Citric acid, magnesium salt (2:3); LS-3185; Citric acid (8CI); 1,2,3-Propanetricarboxylic acid, 2-hydroxy-; Citretten; Chemfill; Kyselina citronova; HSDB 911; Anhydrous citric acid (JP15); Inhibitor; Iron, [hydrogen citrato(3-)]-
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DrugBank
Identification
| Name: | Citric Acid |
|---|---|
| Name (isomeric): | DB04272 |
| Drug Type: | small molecule |
| Description: | A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability. |
| Category: | Anticoagulants, Chelating Agents |
| CAS number: | 77-92-9 |
Interactions
| Drug interaction: |
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|---|
Targets
4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate
| UniProt ID: | P0A955 | ||
|---|---|---|---|
| Gene: | eda | ||
| Actions: | unknown | ||
| References: |
|
Links a guanosine 5'-phosphate to molydopterin (MPT) forming molybdopterin guanine dinucleotide (MGD)
| UniProt ID: | P32173 | ||
|---|---|---|---|
| Gene: | mobA | ||
| Actions: | unknown | ||
| References: |
|
(S)-malate = fumarate + H(2)O
| UniProt ID: | P05042 | ||
|---|---|---|---|
| Gene: | fumC | ||
| Actions: | unknown | ||
| References: |
|
Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate
| UniProt ID: | Q9X0N8 | ||
|---|---|---|---|
| Gene: | pgl | ||
| Actions: | unknown | ||
| References: |
|
Reduction of a variety of nitroaromatic compounds using NADH (and to lesser extent NADPH) as source of reducing equivalents; two electrons are transferred. Capable of reducing nitrofurazone, quinones and the anti-tumor agent CB1954 (5- (aziridin-1-yl)-2,4-dinitrobenzamide). The reduction of CB1954 results in the generation of cytotoxic species
| UniProt ID: | P38489 | ||
|---|---|---|---|
| Gene: | nfnB | ||
| Actions: | unknown | ||
| References: |
|
During replicative cycle of retroviruses, the reverse- transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase
| UniProt ID: | Q04095 | ||
|---|---|---|---|
| Gene: | gag-pro-pol | ||
| Actions: | unknown | ||
| References: |
|
| UniProt ID: | Q96RQ9 | |||
|---|---|---|---|---|
| Gene: | IL4I1 | |||
| Actions: | unknown | |||
| References: |
|
The expression of MIF at sites of inflammation suggest a role for the mediator in regulating the function of macrophage in host defense. Also acts as a phenylpyruvate tautomerase
| UniProt ID: | P14174 | ||
|---|---|---|---|
| Gene: | MIF | ||
| Actions: | unknown | ||
| References: |
|
| UniProt ID: | Q9GZU7 | |||
|---|---|---|---|---|
| Gene: | CTDSP1 | |||
| Actions: | unknown | |||
| References: |
|
Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)
| UniProt ID: | P45568 | ||
|---|---|---|---|
| Gene: | dxr | ||
| Actions: | unknown | ||
| References: |
|
The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate
| UniProt ID: | P16608 | ||
|---|---|---|---|
| Gene: | trpA | ||
| Actions: | unknown | ||
| References: |
|
To release sialic acids for use as carbon and energy sources for this non-pathogenic bacterium while in pathogenic microorganisms, sialidases have been suggested to be pathogenic factors
| UniProt ID: | Q02834 | ||
|---|---|---|---|
| Gene: | nedA | ||
| Actions: | unknown | ||
| References: |
|
| UniProt ID: | P83787 |
|---|---|
| Actions: | unknown |
| UniProt ID: | O14964 | |
|---|---|---|
| Gene: | HGS | |
| Actions: | unknown | |
| References: |
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Invasin is a protein that allows enteric bacteria to penetrate cultured mammalian cells. The entry of invasin in the cell is mediated by binding several beta-1 chain integrins
| UniProt ID: | P11922 |
|---|---|
| Gene: | YPTB1668 |
| Actions: | unknown |
This endonuclease is specific to the thymidylate synthase (td) gene splice junction and is involved in intron homing
| UniProt ID: | P13299 |
|---|---|
| Gene: | ITEVIR |
| Actions: | unknown |
| UniProt ID: | P40926 | |
|---|---|---|
| Gene: | MDH2 | |
| Actions: | unknown | |
| References: |
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Preferential release of a C-terminal lysine or arginine amino acid
| UniProt ID: | P15086 |
|---|---|
| Gene: | CPB1 |
| Actions: | unknown |
| UniProt ID: | Q6L8F0 |
|---|---|
| Actions: | unknown |
This protein is one of the structural proteins in the viral coat and is synthesized during late infection
| UniProt ID: | P03277 |
|---|---|
| Gene: | PII |
| Actions: | unknown |
Hydrolysis of sucrose, raffinose, inulin and levan. Specific for the fructose moiety and the beta-anomeric configuration of the glycosidic linkages of its substrates. The enzyme released fructose from sucrose and raffinose, and the fructose polymer inulin is hydrolyzed quantitatively in an exo- type fashion
| UniProt ID: | O33833 |
|---|---|
| Gene: | bfrA |
| Actions: | unknown |
Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps:(A) adenylation of the enzyme by ATP; (B) the enzyme acts on RNA-N3'P to produce RNA-N3'PP5'A; (C) a non catalytic nucleophilic attack by the adjacent 2'hydroxyl on the phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing
| UniProt ID: | P46849 |
|---|---|
| Gene: | rtcA |
| Actions: | unknown |
| UniProt ID: | P62312 | |
|---|---|---|
| Gene: | LSM6 | |
| Actions: | unknown | |
| References: |
|
Binds specifically to phosphatidylinositol-3,4- diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane
| UniProt ID: | Q9HB21 |
|---|---|
| Gene: | PLEKHA1 |
| Actions: | unknown |
Part of the ABC transporter complex fbpABC (TC 3.A.1.10.1) involved in Fe(3+) ions import. This protein specifically binds Fe(3+) and is involved in its transmembrane transport (By similarity)
| UniProt ID: | P21408 |
|---|---|
| Gene: | fbpA |
| Actions: | unknown |
Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
| UniProt ID: | P0A753 |
|---|---|
| Gene: | nadD |
| Actions: | unknown |
Involved in the transcription termination process (By similarity)
| UniProt ID: | Q9X286 |
|---|---|
| Gene: | nusB |
| Actions: | unknown |
C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol
| UniProt ID: | P07360 |
|---|---|
| Gene: | C8G |
| Actions: | unknown |
Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
| UniProt ID: | Q9CBQ2 |
|---|---|
| Gene: | nrdF |
| Actions: | unknown |
| UniProt ID: | Q7SIC5 |
|---|---|
| Actions: | unknown |
| UniProt ID: | Q9GV41 |
|---|---|
| Gene: | Tb11.02.2310 |
| Actions: | unknown |
This protein is essential to the cell-division process. It seems to assemble into a dynamic ring on the inner surface of the cytoplasmic membrane at the place where division will occur, and the formation of the ring is the signal for septation to begin. Binds to and hydrolyzes GTP
| UniProt ID: | P64170 | ||
|---|---|---|---|
| Gene: | ftsZ | ||
| Actions: | unknown | ||
| References: |
|
Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
| UniProt ID: | P07741 | |
|---|---|---|
| Gene: | APRT | |
| Actions: | unknown | |
| References: |
|
May function as a tRNA-specific ribonuclease that binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus, thereby promoting the endothelial invasiveness necessary for blood vessel formation. Angiogenin induces vascularization of normal and malignant tissues. Abolishes protein synthesis by specifically hydrolyzing cellular tRNAs
| UniProt ID: | P03950 | ||
|---|---|---|---|
| Gene: | ANG | ||
| Actions: | unknown | ||
| References: |
|
Can hydrolyze carbapenem compounds
| UniProt ID: | P04190 | ||
|---|---|---|---|
| Gene: | blm | ||
| Actions: | unknown | ||
| References: |
|
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, 4-N-acetylcytidine, 4-N- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and 4-N-anisoylcytidine
| UniProt ID: | Q9BZX2 | ||
|---|---|---|---|
| Gene: | UCK2 | ||
| Actions: | unknown | ||
| References: |
|
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response
| UniProt ID: | Q9Y275 | ||
|---|---|---|---|
| Gene: | TNFSF13B | ||
| Actions: | unknown | ||
| References: |
|
Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline
| UniProt ID: | Q93088 | ||
|---|---|---|---|
| Gene: | BHMT | ||
| Actions: | unknown | ||
| References: |
|
ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp)
| UniProt ID: | P00953 | ||
|---|---|---|---|
| Gene: | trpS | ||
| Actions: | unknown | ||
| References: |
|
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies
| UniProt ID: | P15121 | ||
|---|---|---|---|
| Gene: | AKR1B1 | ||
| Actions: | unknown | ||
| References: |
|
| UniProt ID: | Q9BY32 | |
|---|---|---|
| Gene: | ITPA | |
| Actions: | unknown | |
| References: |
|
| UniProt ID: | O75390 | |||
|---|---|---|---|---|
| Gene: | CS | |||
| Actions: | unknown | |||
| References: |
|
Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity (By similarity)
| UniProt ID: | Q37875 |
|---|---|
| Gene: | 17 |
| Actions: | unknown |
Transfers a sulfuryl group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate. Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate
| UniProt ID: | Q9Y663 | ||
|---|---|---|---|
| Gene: | HS3ST3A1 | ||
| Actions: | unknown | ||
| References: |
|
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP
| UniProt ID: | O76074 | ||
|---|---|---|---|
| Gene: | PDE5A | ||
| Actions: | unknown | ||
| References: |
|
| UniProt ID: | P12931 | |||
|---|---|---|---|---|
| Gene: | SRC | |||
| Actions: | unknown | |||
| References: |
|
Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA
| UniProt ID: | P07998 | |||
|---|---|---|---|---|
| Gene: | RNASE1 | |||
| Actions: | unknown | |||
| References: |
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Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH
| UniProt ID: | P39126 | ||
|---|---|---|---|
| Gene: | icd | ||
| Actions: | unknown | ||
| References: |
|
Catalyzes the methylation of glycine by using S- adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine
| UniProt ID: | Q14749 | ||
|---|---|---|---|
| Gene: | GNMT | ||
| Actions: | unknown | ||
| References: |
|
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity
| UniProt ID: | P12724 | ||
|---|---|---|---|
| Gene: | RNASE3 | ||
| Actions: | unknown | ||
| References: |
|
A beta-lactam + H(2)O = a substituted beta- amino acid
| UniProt ID: | P00808 | ||
|---|---|---|---|
| Gene: | penP | ||
| Actions: | unknown | ||
| References: |
|
Transporters
Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost
| UniProt ID: | O94956 | |
|---|---|---|
| Gene: | SLCO2B1 | |
| Actions: | inhibitor | |
| References: |
|
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