Name: | Thioctic Acid |
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PubChem Compound ID: | 1549102 |
Description: | An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS. |
Molecular formula: | C8H13O2S2- |
Molecular weight: | 205.32 g/mol |
Synonyms: |
1077-28-7; ZINC01532729
|
Name: | Thioctic Acid |
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Name (isomeric): | DB00166 |
Drug Type: | small molecule |
Description: | An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS. |
Synonyms: |
Lipoate; 1,2-Dithiolane-3R-pentanoic acid; Thioctic acid; alpha-Lipoic acid
|
Brand: | Biletan, Thioctsan, Heparlipon |
Category: | Micronutrient, Vitamin B Complex, Antioxidants, Dietary supplement, Vitamins (Vitamin B Complex) |
CAS number: | 62-46-4 |
Indication: | For nutritional supplementation, also for treating dietary shortage or imbalance. |
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Pharmacology: |
Lipoic acid (or α-lipoic acid) is able to pass the blood-brain barrier and is putatively used for detoxification of mercury attached to the brain cells. It can mobilise bound mercury into the blood stream as it is a mercaptan (sulfur compound which readily binds to the mercury). In the blood stream, another chelator such as dimercaptosuccinic...
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Mechanism of Action: |
Lipoic Acid is generally involved in oxidative decarboxylations of keto acids and is presented as a growth factor for some organisms. Lipoic acid exists as two enantiomers, the R-enantiomer and the S-enantiomer. Normally only the R-enantiomer of an amino acid is biologically active, but for lipoic acid the S-enantiomer assists in the reduction of t...
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Affected organisms: | Humans and other mammals |