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QuickView for alpha lipoic acid (compound)


PubChem
Name: Thioctic Acid
PubChem Compound ID: 1549102
Description: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Molecular formula: C8H13O2S2-
Molecular weight: 205.32 g/mol
Synonyms:
1077-28-7; ZINC01532729
DrugBank
Identification
Name: Thioctic Acid
Name (isomeric): DB00166
Drug Type: small molecule
Description: An octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
Synonyms:
Lipoate; 1,2-Dithiolane-3R-pentanoic acid; Thioctic acid; alpha-Lipoic acid
Brand: Biletan, Thioctsan, Heparlipon
Category: Micronutrient, Vitamin B Complex, Antioxidants, Dietary supplement, Vitamins (Vitamin B Complex)
CAS number: 62-46-4
Pharmacology
Indication: For nutritional supplementation, also for treating dietary shortage or imbalance.
Pharmacology:
Lipoic acid (or α-lipoic acid) is able to pass the blood-brain barrier and is putatively used for detoxification of mercury attached to the brain cells. It can mobilise bound mercury into the blood stream as it is a mercaptan (sulfur compound which readily binds to the mercury). In the blood stream, another chelator such as dimercaptosuccinic...
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Mechanism of Action:
Lipoic Acid is generally involved in oxidative decarboxylations of keto acids and is presented as a growth factor for some organisms. Lipoic acid exists as two enantiomers, the R-enantiomer and the S-enantiomer. Normally only the R-enantiomer of an amino acid is biologically active, but for lipoic acid the S-enantiomer assists in the reduction of t...
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Affected organisms: Humans and other mammals

Targets


Enzymes