QuickView for alpha-synuclein (gene)

GO Molecular Function

actin binding | fatty acid binding | endopeptidase inhibitor activity | transcription regulatory region DNA binding | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | cation binding | alpha-tubulin binding | magnesium ion binding | carboxylic acid binding | enzyme binding | nucleic acid binding | protein-containing complex binding | ferrous iron binding | lipid binding | iron ion binding | enzyme inhibitor activity | phospholipid binding | molecular function regulator | catalytic activity | beta-tubulin binding | protein domain specific binding | protein N-terminus binding | Hsp70 protein binding | cytoskeletal protein binding | anion binding | kinesin binding | tau protein binding | dynein complex binding | DNA binding | lipase inhibitor activity | identical protein binding | phospholipase D inhibitor activity | ion binding | organic cyclic compound binding | cuprous ion binding | copper ion binding | phosphoprotein binding | protein binding | zinc ion binding | histone binding | transition metal ion binding | microtubule binding | calcium ion binding | phospholipase inhibitor activity | cysteine-type endopeptidase regulator activity involved in apoptotic process | tubulin binding | peptidase inhibitor activity | enzyme regulator activity | phospholipase binding | heat shock protein binding | organic acid binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | cysteine-type endopeptidase inhibitor activity | small molecule binding

GO Biological Process

positive regulation of release of sequestered calcium ion into cytosol | negative regulation of G-protein coupled receptor protein signaling pathway | negative regulation of thrombin-activated receptor signaling pathway | negative regulation of phosphorylation | regulation of supramolecular fiber organization | purine ribonucleotide metabolic process | regulation of cysteine-type endopeptidase activity | endopeptidase inhibitor activity | regulation of microtubule polymerization or depolymerization | response to cytokine | response to interleukin-1 | positive regulation of cellular component organization | response to lipopolysaccharide | regulation of cellular localization | dopamine uptake involved in synaptic transmission | regulation of synapse assembly | positive regulation of apoptotic process | regulation of localization | catechol-containing compound metabolic process | regulation of carbohydrate metabolic process | regulation of programmed cell death | cysteine-type endopeptidase inhibitor activity involved in apoptotic process | negative regulation of cysteine-type endopeptidase activity | establishment of localization | regulation of autophagy | regulation of immune system process | negative regulation of neuron death | negative regulation of cellular process | positive regulation of neurotransmitter secretion | negative regulation of RNA biosynthetic process | response to metal ion | excitatory postsynaptic potential | positive regulation of receptor recycling | defense response | response to drug | generation of precursor metabolites and energy | negative regulation of protein phosphorylation | regulation of inositol phosphate biosynthetic process | cellular chemical homeostasis | positive regulation of phosphate metabolic process | regulation of organelle organization | cellular response to epinephrine stimulus | membrane organization | phospholipid metabolic process | intracellular transport | dopamine transport | phenol-containing compound metabolic process | negative regulation of proteolysis | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | regulation of catecholamine secretion | establishment of organelle localization | response to magnesium ion | localization | cellular homeostasis | positive regulation of synaptic transmission | response to desipramine | nucleotide metabolic process | negative regulation of signaling | chemical synaptic transmission | positive regulation of peptidyl-serine phosphorylation | positive regulation of reactive oxygen species metabolic process | regulation of neuronal synaptic plasticity | ATP synthesis coupled electron transport | cellular respiration | negative regulation of microtubule polymerization or depolymerization | ribose phosphate metabolic process | negative regulation of nucleic acid-templated transcription | positive regulation of protein kinase activity | regulation of histone modification | negative regulation of apoptotic process | negative regulation of secretion | positive regulation of oxidoreductase activity | regulation of proteolysis | nucleoside triphosphate metabolic process | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | ribonucleotide metabolic process | negative regulation of peptidyl-lysine acetylation | response to inorganic substance | establishment of localization in cell | negative regulation of cellular metabolic process | regulation of oxidative phosphorylation | negative regulation of neurotransmitter transport | regulation of cellular process | leukocyte activation | regulation of apoptotic process | regulation of chaperone-mediated autophagy | regulation of metabolic process | regulation of protein complex assembly | regulation of cytosolic calcium ion concentration | organelle localization | negative regulation of synaptic transmission, dopaminergic | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | negative regulation of response to drug | cellular component organization | negative regulation of nucleotide metabolic process | cellular lipid metabolic process | calcium ion homeostasis | cellular response to metal ion | response to stimulus | enzyme inhibitor activity | regulation of mitochondrial ATP synthesis coupled electron transport | purine nucleotide metabolic process | monocarboxylic acid metabolic process | cellular response to fibroblast growth factor stimulus | positive regulation of protein metabolic process | positive regulation of peptidase activity | response to cocaine | response to stress | positive regulation of cation transmembrane transport | regulation of response to drug | electron transport chain | positive regulation of cysteine-type endopeptidase activity | programmed cell death | protein destabilization | supramolecular fiber organization | negative regulation of transporter activity | cellular response to inorganic substance | cellular localization | organic hydroxy compound transport | regulation of neurotransmitter uptake | positive regulation of proteolysis | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | regulation of dopamine metabolic process | negative regulation of transport | catecholamine biosynthetic process | cellular response to organic cyclic compound | dopamine uptake | negative regulation of metabolic process | positive regulation of protein serine/threonine kinase activity | regulation of synapse structure or activity | modulation of chemical synaptic transmission | cellular biosynthetic process | mitochondrion organization | response to iron ion | cell-cell signaling | synaptic transmission, dopaminergic | dopamine metabolic process | molecular function regulator | cell surface receptor signaling pathway involved in cell-cell signaling | metal ion homeostasis | regulation of catecholamine metabolic process | regulation of nucleic acid-templated transcription | regulation of membrane potential | regulation of neurotransmitter levels | organic hydroxy compound metabolic process | response to nitrogen compound | negative regulation of neuron apoptotic process | regulation of long-term neuronal synaptic plasticity | apoptotic process | regulation of calcium ion transport into cytosol | synaptic vesicle cycle | response to external biotic stimulus | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of secretion by cell | regulation of protein stability | negative regulation of phosphate metabolic process | positive regulation of calcium ion transmembrane transport | negative regulation of catalytic activity | negative regulation of ATP metabolic process | regulation of peptidase activity | phosphorus metabolic process | positive regulation of inflammatory response | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | lipid metabolic process | cellular response to oxidative stress | regulation of phosphorylation | negative regulation of peptidase activity | synaptic vesicle recycling | regulation of gene expression | regulation of postsynaptic membrane potential | positive regulation of secretion | organic substance transport | cellular response to stress | response to lipid | nervous system process | synaptic signaling | response to epinephrine | organophosphate metabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | cellular ion homeostasis | adult locomotory behavior | regulation of dopamine uptake involved in synaptic transmission | response to ammonium ion | positive regulation of ion transmembrane transport | regulation of synapse organization | regulation of platelet-derived growth factor receptor signaling pathway | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | small molecule metabolic process | lipase inhibitor activity | vesicle-mediated transport | regulation of transcription by RNA polymerase II | dopamine biosynthetic process | response to oxidative stress | synapse organization | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of synaptic transmission, dopaminergic | positive regulation of hydrolase activity | behavioral response to cocaine | regulation of fatty acid metabolic process | nucleobase-containing small molecule metabolic process | phospholipase D inhibitor activity | regulation of release of sequestered calcium ion into cytosol | response to iron(II) ion | establishment of vesicle localization | biosynthetic process | locomotory behavior | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | phosphorylation | negative regulation of ion transport | positive regulation of endopeptidase activity | negative regulation of norepinephrine uptake | regulation of phospholipase activity | regulation of calcium ion transmembrane transport | positive regulation of neuron death | regulation of glutamate secretion | regulation of hydrogen peroxide metabolic process | microglial cell activation | response to xenobiotic stimulus | cation homeostasis | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | phosphate-containing compound metabolic process | negative regulation of autophagy | regulation of macrophage activation | response to bacterium | mitochondrial membrane organization | cellular cation homeostasis | negative regulation of microtubule polymerization | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of neuron apoptotic process | negative regulation of oxidative phosphorylation | receptor internalization | negative regulation of serotonin uptake | synaptic vesicle endocytosis | response to catecholamine | mitochondrial ATP synthesis coupled electron transport | positive regulation of inositol phosphate biosynthetic process | regulation of protein metabolic process | cellular calcium ion homeostasis | homeostatic process | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | positive regulation of transport | regulation of dopamine secretion | regulation of microtubule-based process | drug metabolic process | carboxylic acid metabolic process | positive regulation of molecular function | negative regulation of exocytosis | negative regulation of monooxygenase activity | response to monoamine | protein metabolic process | negative regulation of protein polymerization | positive regulation of protein modification process | response to organic substance | neutral lipid metabolic process | regulation of cellular respiration | catecholamine metabolic process | regulation of kinase activity | negative regulation of dopamine metabolic process | import into cell | regulation of exocytosis | cell surface receptor signaling pathway | metabolic process | neurotransmitter uptake | regulation of microtubule polymerization | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | oxidation-reduction process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | negative regulation of cytoskeleton organization | negative regulation of dopamine uptake involved in synaptic transmission | negative regulation of histone acetylation | regulation of vesicle-mediated transport | chemical homeostasis | endocytosis | regulation of secretion | behavior | positive regulation of cell death | negative regulation of cellular respiration | oxidative phosphorylation | macrophage activation | immune response | nucleobase-containing compound metabolic process | negative regulation of protein complex assembly | organic substance metabolic process | regulation of sequestering of calcium ion | response to copper ion | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | positive regulation of ion transport | regulation of norepinephrine uptake | negative regulation of cellular protein metabolic process | regulation of cell activation | positive regulation of programmed cell death | positive regulation of kinase activity | ion homeostasis | regulation of ATP metabolic process | regulation of phosphate metabolic process | regulation of chromosome organization | response to alkaloid | regulation of ion transmembrane transport | positive regulation of glutathione peroxidase activity | fatty acid metabolic process | regulation of serotonin uptake | regulation of acyl-CoA biosynthetic process | response to interferon-gamma | cell activation | regulation of mitochondrial electron transport, NADH to ubiquinone | drug transport | regulation of reactive oxygen species biosynthetic process | regulation of peptidyl-serine phosphorylation | adult behavior | negative regulation of protein catabolic process | negative regulation of protein metabolic process | positive regulation of carbohydrate metabolic process | regulation of cell communication | phospholipase inhibitor activity | cysteine-type endopeptidase regulator activity involved in apoptotic process | negative regulation of chromosome organization | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | response to organic cyclic compound | regulation of endocytosis | synaptic vesicle localization | regulation of transmembrane transporter activity | organic acid metabolic process | positive regulation of phosphorylation | peptidase inhibitor activity | cellular protein metabolic process | enzyme regulator activity | regulation of endopeptidase activity | cation transport | positive regulation of calcium ion transport into cytosol | response to biotic stimulus | regulation of synaptic vesicle recycling | ammonium transport | regulation of cellular ketone metabolic process | regulation of nervous system development | regulation of developmental process | regulation of ion transport | receptor-mediated endocytosis | regulation of G-protein coupled receptor protein signaling pathway | energy derivation by oxidation of organic compounds | developmental process | organelle organization | negative regulation of mitochondrial electron transport, NADH to ubiquinone | regulation of calcium ion transport | monoamine transport | regulation of histone acetylation | negative regulation of transcription by RNA polymerase II | carbohydrate derivative metabolic process | regulation of transport | regulation of reactive oxygen species metabolic process | regulation of receptor recycling | innate immune response | neurotransmitter transport | response to fibroblast growth factor | negative regulation of oxidoreductase activity | receptor metabolic process | negative regulation of protein acetylation | response to organonitrogen compound | cellular metal ion homeostasis | negative regulation of supramolecular fiber organization | heterocycle metabolic process | negative regulation of hydrolase activity | negative regulation of synaptic transmission | regulation of anion transport | response to anesthetic | regulation of generation of precursor metabolites and energy | regulation of lipid metabolic process | positive regulation of metabolic process | regulation of synaptic plasticity | vesicle localization | ion transport | immune system process | cellular metabolic process | negative regulation of platelet-derived growth factor receptor signaling pathway | long-term synaptic potentiation | ATP metabolic process | synaptic vesicle transport | cellular response to organic substance | regulation of cell death | cellular response to copper ion | oxidoreductase activity | cysteine-type endopeptidase inhibitor activity | positive regulation of hydrogen peroxide catabolic process | negative regulation of cell death | regulation of inflammatory response | aging | negative regulation of chaperone-mediated autophagy | divalent inorganic cation homeostasis | positive regulation of endocytosis | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | positive regulation of calcium ion transport | regulation of presynapse assembly | regulation of cytoskeleton organization | response to other organism | positive regulation of signaling | cellular response to catecholamine stimulus | signal transduction | regulation of signaling | negative regulation of endopeptidase activity | regulation of neurotransmitter secretion | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | respiratory electron transport chain | regulation of chromatin organization | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | supramolecular fiber | mitochondrial matrix | exocytic vesicle | mitochondrial intermembrane space | organelle inner membrane | intracellular membrane-bounded organelle | synapse | catalytic complex | mitochondrial inner membrane | neuron projection | somatodendritic compartment | organelle membrane | nuclear membrane | cytoplasmic vesicle | platelet alpha granule membrane | cell body | cell | oxidoreductase complex | organelle outer membrane | neuronal cell body | distal axon | mitochondrial respiratory chain complex I | terminal bouton | cytoplasm | respiratory chain complex I | intracellular organelle | ribosome | actin cytoskeleton | endoplasmic reticulum | platelet alpha granule | secretory granule membrane | presynapse | inclusion body | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | cell projection | secretory vesicle | endomembrane system | postsynapse | plasma membrane | nuclear envelope | vacuole | ribonucleoprotein complex | vesicle | transport vesicle | mitochondrial respiratory chain | perinuclear region of cytoplasm | respiratory chain | cytoplasmic region | mitochondrion | site of polarized growth | nuclear outer membrane | lytic vacuole | synaptic vesicle | extracellular region | cell cortex | membrane-bounded organelle | nucleus | organelle | mitochondrial outer membrane | vesicle membrane | axon terminus | mitochondrial envelope | lysosome | extracellular space | cell periphery | axon | membrane-enclosed lumen | outer membrane | growth cone | neuron projection terminus | mitochondrial membrane | rough endoplasmic reticulum | cytosol | intracellular vesicle | cytoskeleton | intracellular | cell junction | membrane | supramolecular complex | cytoplasmic vesicle membrane

PATHWAYS

PID_ALPHA_SYNUCLEIN_PATHWAY | REACTOME_AMYLOIDS

PROTEIN FAMILY

Synuclein | Alpha-synuclein