Name: | Aluminum Hydroxide |
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PubChem Compound ID: | 10176082 |
Description: | A compound with many biomedical applications: as a gastric antacid, an antiperspirant, in dentifrices, as an emulsifier, as an adjuvant in bacterins and vaccines, in water purification, etc. |
Molecular formula: | AlH3O3 |
Molecular weight: | 78.0036 g/mol |
Name: | Aluminum Hydroxide |
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Name (isomeric): | DB06723 |
Drug Type: | small molecule |
Description: | A compound with many biomedical applications: as a gastric antacid, an antiperspirant, in dentifrices, as an emulsifier, as an adjuvant in bacterins and vaccines, in water purification, etc. |
Brand: | AlternaGel, Amphojel, Alu-Cap |
Category: | Antacids |
Indication: | For relief of heartburn and acid indigestion. |
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Pharmacology: |
Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and pr...
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Mechanism of Action: |
Aluminum hydroxide is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. Aluminum hydroxide is slowly solubilized in the stomach and reacts with hydrochloric acid to form aluminum chloride and water. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur...
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Absorption: | Approximately 17-30% of the aluminum chloride formed is absorbed. |
Biotransformation: | Not metabolized. |
Route of elimination: | Absorbed aluminum chloride is rapidly eliminated by the kidneys in patients with normal renal function. |
Drug interaction: |
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