QuickView for amoxicillin (compound)

CLAMOXYQUIN DIHYDROCHLORIDE; Clamoxyl (TN); 8-Quinolinol, 5-chloro-7-(((3-(diethylamino)propyl)amino)methyl)-, dihydrochloride; 5-Chloro-7-(((3-(diethylamino)propyl)amino)methyl)-8-quinolinol dihydrochloride; Clamoxyquin hydrochloride (USAN); CN-17,900-2B; Clamoxyquin hydrochloride; Clamoxyquin hydrochloride [USAN]; D03529; CI 433.
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CLAMOXYQUIN DIHYDROCHLORIDE; Clamoxyl (TN); 8-Quinolinol, 5-chloro-7-(((3-(diethylamino)propyl)amino)methyl)-, dihydrochloride; 5-Chloro-7-(((3-(diethylamino)propyl)amino)methyl)-8-quinolinol dihydrochloride; Clamoxyquin hydrochloride (USAN); CN-17,900-2B; Clamoxyquin hydrochloride; Clamoxyquin hydrochloride [USAN]; D03529; CI 433; KAN 322; PAA 3854 dihydrochloride; 4724-59-8; NSC 20246; Clamoxyl
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Amoxycillin Trihydrate; Amoxicillin Trihydrate; Amoxicillin anhydrous; Amoxycillin; Amoxicilina [INN-Spanish]; p-Hydroxyampicillin; AMC; Amoxicillinum [INN-Latin]; D-Amoxicillin; Amoxicilline [INN-French]

Amoxicillin is a moderate-spectrum antibiotic active against a wide range of Gram-positive, and a limited range of Gram-negative organisms. It is usually the drug of choice within the class because it is better absorbed, following oral administration, than other beta-lactam antibiotics. Amoxicillin is susceptible to degradation by β-lactamase-...
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Amoxicillin is a moderate-spectrum antibiotic active against a wide range of Gram-positive, and a limited range of Gram-negative organisms. It is usually the drug of choice within the class because it is better absorbed, following oral administration, than other beta-lactam antibiotics. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, and so may be given with clavulanic acid to increase its susceptability. The incidence of β-lactamase-producing resistant organisms, including E. coli, appears to be increasing. Amoxicillin is sometimes combined with clavulanic acid, a β-lactamase inhibitor, to increase the spectrum of action against Gram-negative organisms, and to overcome bacterial antibiotic resistance mediated through β-lactamase production.
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Amoxicillin binds to penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage ...
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Amoxicillin binds to penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that amoxicllin interferes with an autolysin inhibitor.
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