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PubChem
| Name: | Amrinone |
|---|---|
| PubChem Compound ID: | 3035194 |
| Description: | A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell. |
| Molecular formula: | C13H15N3O4 |
| Molecular weight: | 277.276 g/mol |
| Synonyms: |
Inamrinone lactate; Propanoic acid, 3-hydroxy-, compd. with 5-amino-(3,4'-bipyridin)-6(1H)-one; 3-Hydroxypropanoic acid compd. with 5-amino-(3,4'-bipyridin)-6(1H)-one; 75898-90-7; Amrinone lactate; (3,4'-Bipyridin)-6(1H)-one, 5-amino-, 3-hydroxypropanoate
|
DrugBank
Identification
| Name: | Amrinone |
|---|---|
| Name (isomeric): | DB01427 |
| Drug Type: | small molecule |
| Description: | A positive inotropic cardiotonic (CARDIOTONIC AGENTS) with vasodilator properties, phosphodiesterase 3 inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell. |
| Synonyms: |
Inamrinone lactate; Amrinonum [inn-latin]; Inamrinone; Amrinona [inn-spanish]
|
| Brand: | Cordarex, Cartonic, Amcoral, Wincoram, Inocor, Cordemcura |
| Category: | Vasodilator Agents, Phosphodiesterase Inhibitors, Cardiotonic Agents, Calcium Channel Blockers |
| CAS number: | 60719-84-8 |
Pharmacology
| Indication: | Used in the treatment of congestive heart failure. |
|---|---|
| Pharmacology: | Amrinone is a positive inotropic cardiotonic with vasodilator properties, phosphodiesterase inhibitory activity, and the ability to stimulate calcium ion influx into the cardiac cell. |
| Mechanism of Action: | Amrinone is a phosphodiesterase inhibitor (PDE3), resulting in increased cAMP and cGMP which leads to an increase in the calcium influx like that caused by beta-agonists resulting in increased inotropic effect. |
| Protein binding: | 10 to 49% |
| Biotransformation: | Hepatic. |
| Route of elimination: | The primary route of excretion in man is via the urine as both inamrinone and several metabolites (N-glycolyl, N-acetate, O-glucuronide and N-glucuronide). |
| Half Life: | 5 to 8 hours |
| Affected organisms: | Humans and other mammals |
Targets
