QuickView for aquaporin 4 (gene)

Gene Symbol:

AQP4 Homo sapiens

Full name:

aquaporin 4

Synonyms:

MIWC, WCH4, aquaporin-4, aquaporin type4, mercurial-insensitive water channel

Genomic Location:

Chr 18: 22686005-22699714

Description:

This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have b...

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This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GATA1_03 ,  CIZ_01 ,  HNF1_C ,  GR_Q6_01 ,  TTF1_Q6 ,  ACTACCT_MIR196A_MIR196B ,  CAGCAGG_MIR370 ,  MTF1_Q4 ,  SNACANNNYSYAGA_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  CTAGGAA_MIR384 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-196 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-384 ,  Predicted Gene Targets for miR-495

Cytogenetic Map:

18q11.2

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