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PubChem

PubChem Compound 10112

PubChem Compound 10112

Name:	Calcium Carbonate
PubChem Compound ID:	10112
Description:	Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.
Molecular formula:	CCaO₃
Molecular weight:	100.087 g/mol
Synonyms:	Franklin; EPA Pesticide Chemical Code 073502; Neolite F; Calopake PC; Hakuenka CCR; CHEBI:3311; C 50 (carbonate); Eskalon 200; Chooz; Kalziumkarbonat. show more » Franklin; EPA Pesticide Chemical Code 073502; Neolite F; Calopake PC; Hakuenka CCR; CHEBI:3311; C 50 (carbonate); Eskalon 200; Chooz; Kalziumkarbonat; Neoanticid; Brilliant BR 15; KS 1500; Mylanta Gelcaps; Camel-carb; Akadama; Durcal 40; Precipitated calcium carbonate (JP15); Ground limestone; Camel-wite; 146358-95-4; Domolite; Eskalon 100; D00932; Carbonic acid calcium salt (1:1); P-Lite 500; C.I. 77220; Calcium carbonate [USAN]; Calofort U; Calofort T; NCC 45; Albaglos; Cal-sup; Finncarb 6002; 114453-69-9; Multifex MM; Di-Gel Tablets; Calcilit 100; Caltrate; Calcitrel; Calofor U 50; Dacote; Camalox; Neolite SP; Calcium carbonate; Non-Fer-Al; Carborex 2; Caltec; Microcarb; Allied whiting; 137803-94-2; Multiflex SC; Durcal 2NH; 251358-28-8; Eskalon 800; Calibrite; Marble white; Calopake F; Brilliant 15; Calopake H; Precipitated chalk; Calcite (Ca(Co3)); Hydrocarb 65; CCC No.AA oolitic; KS 500; 60083-79-6; 71060-88-3; Calcilit 8; NS 100; Hydrocarb; BRT 30; Duramite; EINECS 207-439-9; Kredafil 150 Extra; Calofil E 2; KS 2100; K 250; Monocalcium carbonate; Hakuenka R 06; Calcium carbonate (USP); Portland stone; Hakuenka T-DD; Calseeds; Natural calcium carbonate; P-Lite 700; Camel-tex; Cal-Light SA; Hydrocarb 60; Cal-sup (TN); 72608-12-9; 63660-97-9; 180616-31-3; Carbium; KS 1800; 39454-55-2; Crystic prefil S; Mylanta Soothing Lozenges; T 130-2500; Micromic CR 16; Filtex White Base; Marfil; 1317-65-3; Precipitated calcium carbonate; Limestone; LS-2385; Calwhite; Neolite TPS; AX 363; Chalk; NCC-P; calcium trioxidocarbonate; Agstone; Calcene CO; Hakuenka PX; Marble dust; Hakuenka PZ; DOMAR; Calcene TM; Kotamite; Microwhite 25; BRT 1500; Atomite; Calcidar 40; Albacar 5970; BS 32; 471-34-1; Durcal C 640305; Caswell No. 139; N 34; Tylenol Headache Plus; Carbium MM; Carbonic acid, calcium salt (1:1); Garolite SA; EGRI M 5; Titralac; NS 2500; BF 200; CCC G-white; CCRIS 1333; Sohnhofen stone; Calcium monocarbonate; Levigated chalk; NS 200; Calmos; MSK-PO; MSK-K; Calofil B 1; Micromya; Calcium carbonate, precipitated; Agricultural limestone; Chemcarb; CI 77220; MSK-P; Eskalon 400; MSK-V; Albaglos SF; Calcium carbonate slurry; Albacar; Hakuenka DD; KULU 40; Marblewhite 325; Bell mine pulverized limestone; Calofort S; R Jutan; Marble; Albafil; Calmote; Kredafil RM 5; N 43; 172307-27-6; KS 1300; Gilder's whiting; Carbital 90; Hakuenka O; Calopake high opacity; MSK-C; C.I. Pigment White 18; MSK-G; Lithograpic stone; Calcicoll; Carusis P; Calofil A 4; NS; Durcal 10; Aeromatt; Britomya S; Calcium carbonate (1:1); HSDB 927; CaCO3; Britomya M; Atomit; C08129; Eskalon 1500; Calopake FS; NS 400; Pigment white 18; Calcene NC; Calcite; EINECS 215-279-6; Clefnon; 13397-26-7; CCR; 166516-01-4; Brilliant 1500; Multiflex MM; CCW; MC-T; Hakuenka CC; Homocal D show less «

DrugBank

Identification

Name:	Calcium Carbonate
Name (isomeric):	DB06724
Drug Type:	small molecule
Description:	Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.
Category:	Antacids

Pharmacology

Indication:	For relief of heartburn and acid indigestion. May also be used as a nutritional supplement or to treat hypocalcemia.
Pharmacology:	Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bica... show more » Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bicarbonate and prostaglandin secretion. The acid-neutralizing capacity of calcium carbonate is 58 mEq/15 ml. When used as a nutritional supplement, calcium carbonate acts by directly increasing calcium stores within the body. show less «
Mechanism of Action:	Calcium carbonate is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO₃^-) and prostaglandins. Neutralization of hydrochloric acid resu... show more » Calcium carbonate is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO₃^-) and prostaglandins. Neutralization of hydrochloric acid results in the formation of calcium chloride, carbon dioxide and water. Approximately 90% of calcium chloride is converted to insoluble calcium salts (e.g. calcium carbonate and calcium phosphate). show less «
Absorption:	Maximal absorption occurs at doses of 500 mg or less taken with food. Oral bioavailability depends on intestinal pH, the presence of food and dosage.
Protein binding:	Calcium acts as a co-factor to numerous enzymes.
Biotransformation:	None.
Route of elimination:	Excreted mainly in the feces. The majority of renally filtered calcium is reabsorbed in the ascending limb of the loop of Henle and the proximal and distal convoluted tubules. Also secreted by sweat glands.
Affected organisms:	Humans and other mammals

Interactions

Food interaction:

Food increases the absorption of calcium carbonate.

Drug interaction:

Calcium Chloride	Calcium salts may enhance the adverse/toxic effect of calcium chloride. Concurrent use of other calcium salts with calcium acetate should be avoided when possible. This combination is particularly dangerous in patients with other risk factors for hypercalcemia, such as those with end-stage renal disease.
Itraconazole	The antacid, calcium carbonate, may decrease the effect of itraconazole by decreasing its absorption.
Calcium Acetate	Calcium salts may enhance the adverse/toxic effect of calcium acetate. Concurrent use of other calcium salts with calcium acetate should be avoided when possible. This combination is particularly dangerous in patients with other risk factors for hypercalcemia, such as those with end-stage renal disease.