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Name: Arginine
PubChem Compound ID: 1549073
Description: An essential amino acid that is physiologically active in the L-form.
Molecular formula: C6H15N4O2+
Molecular weight: 175.209 g/mol
CHEBI:32682; L-arginine monocation; (2S)-2-ammonio-5-guanidiniopentanoate; L-argininium; L-argininium(1+); ZINC01532525; 74-79-3
Name: Arginine
Name (isomeric): DB00125
Drug Type: small molecule
Description: An essential amino acid that is physiologically active in the L-form.
L-a-Amino-d-guanidinovaleric acid; L-Arg; 2-Amino-5-guanidinovaleric acid; Arginine; L-(+)-Arginine; (S)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid
Brand: Minophagen A, Detoxargin, Argamine, Levargin, Argivene, R-Gene 10 (Pharmacia Corp.)
Category: Micronutrient, Conditionally Essential Amino Acids, Dietary supplement
CAS number: 74-79-3
Indication: Used for nutritional supplementation, also for treating dietary shortage or imbalance.
Pharmacology: Studies have shown that is has improved immune responses to bacteria, viruses and tumor cells; promotes wound healing and regeneration of the liver; causes the release of growth hormones; considered crucial for optimal muscle growth and tissue repair.
Mechanism of Action:
Many of supplemental L-arginine's activities, including its possible anti-atherogenic actions, may be accounted for by its role as the precursor to nitric oxide or NO. NO is produced by all tissues of the body and plays very important roles in the cardiovascular system, immune system and nervous system. NO is formed from L-arginine via the enzyme n...
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Absorption: Absorbed from the lumen of the small intestine into the enterocytes. Absorption is efficient and occurs by an active transport mechanism.
Biotransformation: Some metabolism of L-arginine takes place in the enterocytes. L-arginine not metabolized in the enterocytes enters the portal circulation from whence it is transported to the liver, where again some portion of the amino acid is metabolized.
Toxicity: Oral supplementation with L-arginine at doses up to 15 grams daily are generally well tolerated. The most common adverse reactions of higher doses from 15 to 30 grams daily are nausea, abdominal cramps and diarrhea. Some may experience these symptoms at lower doses.
Affected organisms: Humans and other mammals