QuickView for atrogin 1 (gene)

Gene Symbol:

FBXO32 Homo sapiens

Full name:

F-box protein 32

Synonyms:

Fbx32, MAFbx, F-box only protein 32, atrogin 1, muscle atrophy F-box protein

Genomic Location:

Chr 8: 124584539-124622627

Description:

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided i...

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This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

POU6F1_01 ,  MYOD_Q6_01 ,  TCANNTGAY_SREBP1_01 ,  ROAZ_01 ,  GCANCTGNY_MYOD_Q6 ,  TAAYNRNNTCC_UNKNOWN ,  CTTTGA_LEF1_Q2 ,  CAGGTG_E12_Q6 ,  MYOD_Q6 ,  ATACTGT_MIR144 ,  MEIS1AHOXA9_01 ,  TTGTTT_FOXO4_01 ,  TGATTTRY_GFI1_01 ,  TGACATY_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-144

Cytogenetic Map:

8q24.13

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