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QuickView for auranofin (compound)
PubChem
| Name: | Auranofin |
|---|---|
| PubChem Compound ID: | 10228443 |
| Description: | An oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. Its exact mechanism of action is unknown, but it is believed to act via immunological mechanisms and alteration of lysosomal enzyme activity. Its efficacy is slightly less than that of injected gold salts, but it is better tolerated, and side effects which occur are potentially less serious. |
| Molecular formula: | C23H26N8O3S |
| Molecular weight: | 494.571 g/mol |
DrugBank
Identification
| Name: | Auranofin |
|---|---|
| Name (isomeric): | DB00995 |
| Drug Type: | small molecule |
| Description: | An oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. Its exact mechanism of action is unknown, but it is believed to act via immunological mechanisms and alteration of lysosomal enzyme activity. Its efficacy is slightly less than that of injected gold salts, but it is better tolerated, and side effects which occur are potentially less serious. |
| Synonyms: |
Auroafen
|
| Brand: | Ridaura |
| Category: | Antirheumatic Agents, Gold |
| CAS number: | 34031-32-8 |
Pharmacology
| Indication: | Used in the treatment of active, progressive or destructive forms of inflammatory arthritis, such as adult rheumatoid arthritis. |
|---|---|
| Pharmacology: | Auranofin is a gold salt used in treating inflammatory arthritis. Gold salts are called second-line drugs because they are often considered when the arthritis progresses in spite of antiinflammatory drugs (NSAIDs and corticosteroids). |
| Mechanism of Action: |
Exactly how auranofin works is not well understood. It may act as an inhibitor of kappab kinase and thioredoxin reductase which would lead to a decreased immune response and decreased free radical production, respectively. In patients with inflammatory arthritis, such as adult and juvenile rheumatoid arthritis, gold salts can decrease the inflammat...
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| Route of elimination: | Approximately 60% of the absorbed gold (15% of the administered dose) from a single dose of auranofin is excreted in urine; the remainder is excreted in the feces. |
| Toxicity: | Oral, rat: LD50 = > 2000 mg/kg. Symptoms of overdose may include diarrhoea, vomiting, abdominal cramps, and symptoms of hypersensitivity (such as skin rash, hives, itching, and difficulty breathing). |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
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Targets
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