Name: | Bepridil |
---|---|
PubChem Compound ID: | 2351 |
Description: | A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. |
Molecular formula: | C24H34N2O |
Molecular weight: | 366.54 g/mol |
Synonyms: |
C06847; NINDS_000110; Bio2_000501; 68099-86-5; KBio1_000110; Spectrum4_000797; Spectrum_001745; Bio1_000388; Bepridil; KBio2_004793.
show more » |
Name: | Bepridil |
---|---|
Name (isomeric): | DB01244 |
Drug Type: | small molecule |
Description: | A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist. |
Synonyms: |
Bepadin
|
Brand: | Vascor |
Category: | Vasodilator Agents, Antiarrhythmic Agents, Calcium Channel Blockers, Anti-Arrhythmia Agents, Antihypertensive Agents |
CAS number: | 64706-54-3 |
Indication: | For the treatment of chronic stable angina (classic effort-associated angina). |
---|---|
Pharmacology: | Bepridil is a calcium channel blocker that has well characterized anti-anginal properties and known but poorly characterized type 1 anti-arrhythmic and anti-hypertensive properties. It is not related chemically to other calcium channel blockers such as diltiazem hydrochloride, nifedipine and verapamil hydrochloride. |
Mechanism of Action: |
Bepridil has inhibitory effects on both the slow calcium (L-type) and fast sodium inward currents in myocardial and vascular smooth muscle, interferes with calcium binding to calmodulin, and blocks both voltage and receptor operated calcium channels. Bepridil inhibits the transmembrane influx of calcium ions into cardiac and vascular smooth muscle....
show more » |
Absorption: | Rapidly and completely absorbed after oral administration. |
Protein binding: | 99% |
Biotransformation: | Hepatic. |
Half Life: | 24-50 hours |
Toxicity: | There has been one experience with overdosage in which a patient inadvertently took a single dose of 1600 mg of bepridil. The patient was observed for 72 hours in intensive care, but no significant adverse experiences were noted. |
Affected organisms: | Humans and other mammals |
Food interaction: |
| ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
Drug interaction: |
|