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QuickView for beta-glucuronidase (gene)


Gene Symbol:
GUSB Homo sapiens Homo sapiens
Full name:
glucuronidase beta
Synonyms:
BG, MPS7, beta-glucuronidase, beta-D-glucuronidase, beta-G1
Genomic Location:
Chr 7: 65063106-65084681
Description:
This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pse...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Canis lupus familiaris Gallus gallus Pan troglodytes Bos taurus Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 7
7q11.21





GO Molecular Function

signaling receptor binding | hydrolase activity | hydrolase activity, hydrolyzing O-glycosyl compounds | catalytic activity | protein domain specific binding | hydrolase activity, acting on glycosyl bonds | beta-glucuronidase activity | carbohydrate binding | protein binding

GO Biological Process

exocytosis | neutrophil activation | establishment of localization | glucuronoside metabolic process | cellular process | secretion | organic substance catabolic process | leukocyte degranulation | localization | carbohydrate derivative catabolic process | glycosaminoglycan catabolic process | carbohydrate catabolic process | leukocyte activation | catabolic process | response to stimulus | neutrophil degranulation | carboxylic acid catabolic process | leukocyte activation involved in immune response | secretion by cell | nitrogen compound metabolic process | leukocyte mediated immunity | hyaluronan metabolic process | glycoside catabolic process | small molecule metabolic process | cellular carbohydrate metabolic process | cellular carbohydrate catabolic process | vesicle-mediated transport | regulated exocytosis | carbohydrate metabolic process | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | carboxylic acid metabolic process | metabolic process | glycoside metabolic process | immune response | organic substance metabolic process | cell activation | organonitrogen compound catabolic process | organic acid metabolic process | carbohydrate derivative metabolic process | glucuronoside catabolic process | neutrophil mediated immunity | immune system process | cellular metabolic process | hyaluronan catabolic process | glycosaminoglycan metabolic process | macromolecule metabolic process

GO Cellular Component

secretory granule | azurophil granule lumen | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | vacuolar lumen | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | ficolin-1-rich granule lumen | secretory vesicle | endomembrane system | vacuole | vesicle | extracellular exosome | lytic vacuole | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | lysosome | extracellular space | membrane-enclosed lumen | azurophil granule | lysosomal lumen | secretory granule lumen | intracellular vesicle | intracellular | membrane | vesicle lumen