Name: | Bleomycin |
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PubChem Compound ID: | 11980859 |
Description: | A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. |
Molecular formula: | C110H168N37O42S5+ |
Molecular weight: | 2841.07 g/mol |
Synonyms: |
NSC125066; Bleomycin sulfate; 11056-06-7
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Name: | Bleomycin |
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Name (isomeric): | DB00290 |
Drug Type: | small molecule |
Description: | A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. |
Synonyms: |
Bleomycin A2; Bleomycinum [INN-Latin]; Bleomycin B2; BLM; Bleomycine [INN-French]; Bleomicina [INN-Spanish]; Bleomycin sulfate; Bleomicin; Bleocin
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Brand: | Blenoxane, Bleo |
Category: | Antimetabolites, Antibiotics, Antineoplastic |
CAS number: | 11056-06-7 |
Indication: | For palliative treatment in the management malignant neoplasm (trachea, bronchus, lung), squamous cell carcinoma, and lymphomas. |
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Pharmacology: |
Bleomycin is an antibiotic which has been shown to have antitumor activity. Bleomycin selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of mitomycin-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed. Bleomycin...
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Mechanism of Action: |
Although the exact mechanism of action of bleomycin is unknown, available evidence would seem to indicate that the main mode of action is the inhibition of DNA synthesis with some evidence of lesser inhibition of RNA and protein synthesis. DNA cleavage by bleomycin depends on oxygen and metal ions, at least in vitro. It is believed that bleomycin c...
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Absorption: | Systemic absorption is approximately 45%. |
Protein binding: | 1% |
Biotransformation: | Hepatic |
Route of elimination: | It was reported that patients with moderately severe renal failure excreted less than 20% of the dose in the urine. |
Half Life: | 115 minutes |
Toxicity: | Excessive exposure may cause fever, chills, nausea, vomiting, mental, confusion, and wheezing. Bleomycin may cause irritation to eyes, skin and respiratory tract. It may also cause a darkening or thickening of the skin. It may cause an allergic reaction. |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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