QuickView for bmp7 (gene)

Gene Symbol:

BMP7 Homo sapiens

Full name:

bone morphogenetic protein 7

Synonyms:

OP-1, bone morphogenetic protein 7, osteogenic protein 1

Genomic Location:

Chr 20: 55178962-55274708

Description:

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subuni...

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This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

MYOD_Q6_01 ,  GATA1_01 ,  TCANNTGAY_SREBP1_01 ,  RYTTCCTG_ETS2_B ,  ATGTCAC_MIR489 ,  AML_Q6 ,  E2F1_Q4_01 ,  MYCMAX_03 ,  YTATTTTNR_MEF2_02 ,  CACGTG_MYC_Q2 ,  AAAYWAACM_HFH4_01 ,  E2F_Q6_01 ,  CTTTGA_LEF1_Q2 ,  TCF4_Q5 ,  GGGAGGRR_MAZ_Q6 ,  AR_Q6 ,  LEF1_Q6 ,  CAGGTA_AREB6_01 ,  MEF2_01 ,  YYCATTCAWW_UNKNOWN ,  CAGGTG_E12_Q6 ,  SP3_Q3 ,  GGGCGGR_SP1_Q6 ,  E2F_03 ,  E2F_Q4_01 ,  GATA1_05 ,  E2F_Q3_01 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-542-3p

Cytogenetic Map:

20q13.31

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