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QuickView for botulinum%20toxin%20type%20B (compound)
PubChem Substance
| Name: | rimabotulinumtoxinB |
|---|---|
| PubChem Substance ID: | 3791687 |
| Synonyms: |
Botulin B; NeuroBloc; Myobloc; Botulin toxin B; EINECS 297-255-5; Toxins, botulin, B; 93384-44-2
|
DrugBank
Identification
| Name: | rimabotulinumtoxinB |
|---|---|
| Name (isomeric): | DB00042 |
| Drug Type: | biotech |
| Synonyms: |
BTX-B; Botulinum neurotoxin type B precursor
|
| Brand: | Neurobloc (Solstice Neurosciences), Myobloc (Solstice Neurosciences) |
| Category: | Antidystonic Agents |
| CAS number: | 93384-44-2 |
Pharmacology
| Indication: | For the treatment of patients with cervical dystonia to reduce the severity of abnormal head position and neck pain associated with cervical dystonia. |
|---|---|
| Pharmacology: |
Botulinum Toxin Type B inhibits acetylcholine release at the neuromuscular junction via a three stage process: 1) Heavy Chain mediated neurospecific binding of the toxin, 2) internalization of the toxin by receptor-mediated endocytosis, and 3) ATP and pH dependent translocation of the Light Chain to the neuronal cytosol where it acts as a zinc-depe...
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| Mechanism of Action: | Botulinum Toxin Type B binds to and cleaves the synaptic Vesicle Associated Membrane Protein (VAMP, also known as synaptobrevin) which is a component of the protein complex responsible for docking and fusion of the synaptic vesicle to the presynaptic membrane, a necessary step to neurotransmitter release. |
| Absorption: | Though pharmacokinetic or ADME studies were not performed, Botulinum Toxin Type B is not expected to be present in the peripheral blood at measurable levels following IM injection at the recommended doses. |
| Toxicity: | One unit of Botulinum Toxin Type B corresponds to the calculated median lethal intraperitoneal dose (LD50) in mice. |
| Affected organisms: | Humans and other mammals |
Targets
