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Name: Proto-Oncogene Proteins c-kit
Description: A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
Synonyms:
Proto-Oncogene Protein kit; kit Proto Oncogene Protein; p145 c-kit; Proto-Oncogene Protein c-kit; c-kit Receptor; Proto Oncogene Protein kit; c-kit, p145; Receptor, Stem Cell Factor; Proto Oncogene Proteins c kit; c-kit, Proto-Oncogene Proteins.
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