QuickView for c-ABL (gene)
- Gene Symbol:
- ABL1
Homo sapiens - Full name:
- ABL proto-oncogene 1, non-receptor tyrosine kinase
- Synonyms:
- ABL, CHDSKM, JTK7, bcr/abl, c-ABL, c-ABL1, p150, v-abl, tyrosine-protein kinase ABL1, Abelson tyrosine-protein kinase 1, bcr/c-abl oncogene protein, c-abl oncogene 1, receptor tyrosine kinase, proto-oncogene c-Abl, proto-oncogene tyrosine-protein kinase ABL1, v-abl Abelson murine leukemia viral oncogene homolog 1
- Genomic Location:
- Chr 9: 132579089-132752883
- Description:
-
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitous...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
9q34.12
GO Molecular Function
protein phosphorylated amino acid binding | actin binding | ephrin receptor binding | kinase binding | actin filament binding | cation binding | protein kinase binding | magnesium ion binding | enzyme binding | mitogen-activated protein kinase binding | nucleic acid binding | protein-containing complex binding | phosphotyrosine residue binding | ribonucleotide binding | syntaxin binding | SH3 domain binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | nucleotidyltransferase activity | catalytic activity | protein domain specific binding | ATP binding | protein kinase C binding | proline-rich region binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | DNA binding | purine nucleotide binding | neuropilin binding | ion binding | organic cyclic compound binding | nicotinate-nucleotide adenylyltransferase activity | purine ribonucleoside triphosphate binding | phosphoprotein binding | protein tyrosine kinase activity | protein binding | manganese ion binding | transferase activity, transferring phosphorus-containing groups | adenylyltransferase activity | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | transition metal ion binding | SNARE binding | non-membrane spanning protein tyrosine kinase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | actin monomer binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | protein C-terminus binding | small molecule binding | SH2 domain binding
GO Biological Process
positive regulation of immune response | positive regulation of release of sequestered calcium ion into cytosol | leukocyte homeostasis | negative regulation of phospholipase activity | regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | brain development | regulation of supramolecular fiber organization | cell morphogenesis | positive regulation of locomotion | negative regulation of MAPK cascade | actin filament-based process | regulation of microtubule polymerization or depolymerization | positive regulation of microtubule binding | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | immune response-regulating signaling pathway | positive regulation of adherens junction organization | response to lipopolysaccharide | regulation of cellular localization | intracellular signal transduction | positive regulation of apoptotic process | regulation of cell development | regulation of localization | cell-substrate adhesion | morphogenesis of an epithelium | regulation of programmed cell death | negative regulation of lipase activity | positive regulation of peptidyl-tyrosine phosphorylation | peptidyl-amino acid modification | regulation of cell aging | actin cytoskeleton organization | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of autophagy | regulation of osteoblast proliferation | regulation of immune system process | response to dopamine | negative regulation of BMP signaling pathway | negative regulation of cellular process | negative regulation of kinase activity | integrin-mediated signaling pathway | positive regulation of developmental process | substrate adhesion-dependent cell spreading | cell differentiation | immune response-activating cell surface receptor signaling pathway | regulation of T cell differentiation | nervous system development | intrinsic apoptotic signaling pathway in response to DNA damage | response to drug | regulation of extracellular matrix organization | regulation of hematopoietic progenitor cell differentiation | regulation of sprouting angiogenesis | negative regulation of protein phosphorylation | cerebellum morphogenesis | epithelial cell migration | cellular chemical homeostasis | cell part morphogenesis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | regulation of organelle organization | positive regulation of cellular component movement | generation of neurons | positive regulation of protein secretion | B cell differentiation | response to antibiotic | actin filament branching | neuromuscular process controlling balance | regulation of neuron death | cellular process | Fc-gamma receptor signaling pathway involved in phagocytosis | lymphocyte differentiation | regulation of cell motility | localization | cellular homeostasis | cell projection morphogenesis | epithelial tube morphogenesis | regulation of ubiquitin-protein transferase activity | regulation of mitochondrial membrane potential | negative regulation of signaling | developmental growth | neuron development | epithelium migration | immune system development | positive regulation of protein kinase activity | macromolecule localization | negative regulation of apoptotic process | positive regulation of oxidoreductase activity | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | response to inorganic substance | negative regulation of cellular metabolic process | tissue development | regulation of binding | regulation of cell differentiation | positive regulation of muscle cell differentiation | intrinsic apoptotic signaling pathway | DNA damage induced protein phosphorylation | activated T cell proliferation | response to hydrogen peroxide | regulation of angiogenesis | peptidyl-tyrosine autophosphorylation | regulation of immune response | regulation of cellular process | leukocyte activation | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | negative regulation of ubiquitin-protein transferase activity | gliogenesis | catabolic process | regulation of protein complex assembly | regulation of cytosolic calcium ion concentration | cellular response to molecule of bacterial origin | epidermal growth factor receptor signaling pathway | positive regulation of interferon-gamma production | microspike assembly | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | epithelium development | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | regulation of establishment of planar polarity | cellular component organization | calcium ion homeostasis | positive regulation of protein binding | positive regulation of epithelial cell migration | T cell activation | head development | regulation of peptide secretion | regulation of vasculature development | response to stimulus | negative regulation of epithelial cell apoptotic process | thymus development | cell morphogenesis involved in neuron differentiation | regulation of long-term synaptic potentiation | regulation of peptidyl-tyrosine phosphorylation | metencephalon development | embryonic epithelial tube formation | positive regulation of immune system process | positive regulation of protein metabolic process | negative regulation of cell adhesion | mononuclear cell proliferation | regulation of modification of synaptic structure | response to stress | positive regulation of cation transmembrane transport | endothelial cell migration | leukocyte activation involved in immune response | negative regulation of protein kinase activity | regulation of cell proliferation | regulation of protein ubiquitination | positive regulation of actin filament bundle assembly | tube morphogenesis | programmed cell death | supramolecular fiber organization | epithelial tube formation | positive regulation of cytokine secretion | cardiovascular system development | positive regulation of sprouting angiogenesis | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | cellular response to toxic substance | platelet-derived growth factor receptor-beta signaling pathway | immune response-activating signal transduction | positive regulation of blood vessel endothelial cell migration | cellular response to organic cyclic compound | ERBB signaling pathway | regulation of protein transport | negative regulation of metabolic process | regulation of cellular component size | hemopoiesis | cellular component assembly | regulation of axon extension | protein modification process | regulation of actin cytoskeleton reorganization | regulation of synapse structure or activity | regulation of peptide transport | modulation of chemical synaptic transmission | regulation of cell adhesion | embryo development | regulation of morphogenesis of a branching structure | macromolecule modification | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | negative regulation of ERK1 and ERK2 cascade | B cell receptor signaling pathway | activation of protein kinase activity | positive regulation of cell-matrix adhesion | metal ion homeostasis | regulation of lymphocyte differentiation | DNA repair | positive regulation of stress fiber assembly | mitochondrial depolarization | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | regulation of membrane potential | leukocyte differentiation | regulation of cellular response to stress | locomotion | response to nitrogen compound | apoptotic process | regulation of calcium ion transport into cytosol | positive regulation of cell junction assembly | response to external biotic stimulus | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of phosphate metabolic process | positive regulation of calcium ion transmembrane transport | cellular response to antibiotic | regulation of adherens junction organization | regulation of actin cytoskeleton organization | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of MAPK cascade | regulation of BMP signaling pathway | phosphorus metabolic process | regulation of actin filament organization | actin filament organization | neuroepithelial cell differentiation | regulation of axonogenesis | cellular response to DNA damage stimulus | spleen development | regulation of catalytic activity | cerebellum development | regulation of protein serine/threonine kinase activity | regulation of actomyosin structure organization | cellular response to oxidative stress | regulation of phosphorylation | Fc-gamma receptor signaling pathway | cellular response to ammonium ion | regulation of T cell activation | positive regulation of cell cycle | regulation of hematopoietic stem cell differentiation | positive regulation of mitotic cell cycle | signal transduction in response to DNA damage | regulation of small GTPase mediated signal transduction | regulation of neuron differentiation | regulation of gene expression | platelet-derived growth factor receptor signaling pathway | axon development | positive regulation of secretion | neural tube closure | cellular response to stress | response to lipid | nervous system process | cell cycle | cell projection assembly | positive regulation of cellular metabolic process | positive regulation of actin cytoskeleton reorganization | positive regulation of protein phosphorylation | regulation of lymphocyte activation | cellular ion homeostasis | response to ammonium ion | positive regulation of ion transmembrane transport | regulation of synapse organization | positive regulation of cytosolic calcium ion concentration | protein autophosphorylation | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | negative regulation of cellular response to growth factor stimulus | positive regulation of intracellular signal transduction | neural tube formation | negative regulation of protein serine/threonine kinase activity | vesicle-mediated transport | regulation of cellular component movement | regulation of transcription by RNA polymerase II | alpha-beta T cell differentiation | regulation of endothelial cell apoptotic process | regulation of blood vessel branching | response to oxidative stress | regulation of cell migration involved in sprouting angiogenesis | axonogenesis | B cell homeostasis | positive regulation of cell differentiation | regulation of endothelial cell migration | regulation of release of sequestered calcium ion into cytosol | homeostasis of number of cells | activation of protein kinase C activity | positive regulation of cell migration | regulation of Rho protein signal transduction | B cell activation | cell proliferation | leukocyte proliferation | neural tube development | regulation of cellular protein metabolic process | positive regulation blood vessel branching | glial cell differentiation | hindbrain development | positive regulation of non-canonical Wnt signaling pathway | phosphorylation | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | regulation of phospholipase activity | regulation of calcium ion transmembrane transport | positive regulation of neuron death | response to toxic substance | mismatch repair | regulation of epithelial cell apoptotic process | protein phosphorylation | cell morphogenesis involved in differentiation | post-embryonic development | cation homeostasis | immature B cell differentiation | phosphate-containing compound metabolic process | autophagy | B cell proliferation involved in immune response | cellular response to drug | regulation of microtubule binding | response to bacterium | negative regulation of cell-cell adhesion | chordate embryonic development | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | lymphocyte homeostasis | response to catecholamine | astrocyte differentiation | cell activation involved in immune response | positive regulation of cytoskeleton organization | regulation of protein metabolic process | positive regulation of signal transduction | positive regulation of osteoblast proliferation | cellular calcium ion homeostasis | homeostatic process | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of locomotion | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | regulation of stem cell differentiation | negative regulation of protein ubiquitination | positive regulation of transport | regulation of cellular response to growth factor stimulus | apoptotic signaling pathway | embryonic morphogenesis | regulation of mitotic cell cycle | regulation of microtubule-based process | lymphocyte activation | protein tyrosine kinase activity | regulation of phospholipase C activity | positive regulation of molecular function | regulation of cytokine secretion | neuron differentiation | T cell differentiation | response to monoamine | activation of immune response | regulation of cell morphogenesis involved in differentiation | protein metabolic process | positive regulation of focal adhesion assembly | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | gland development | regulation of Cdc42 protein signal transduction | tissue morphogenesis | regulation of hemopoiesis | cell cycle arrest | regulation of kinase activity | DNA metabolic process | regulation of animal organ morphogenesis | import into cell | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | regulation of focal adhesion assembly | anatomical structure development | developmental growth involved in morphogenesis | mitotic cell cycle | cell surface receptor signaling pathway | cell projection organization | metabolic process | positive regulation of cell development | regulation of microtubule polymerization | positive regulation of supramolecular fiber organization | negative regulation of I-kappaB kinase/NF-kappaB signaling | regulation of RNA biosynthetic process | negative regulation of long-term synaptic potentiation | negative regulation of programmed cell death | collateral sprouting | negative regulation of mitotic cell cycle | cellular response to hydrogen peroxide | regulation of vesicle-mediated transport | hindbrain morphogenesis | chemical homeostasis | endocytosis | regulation of secretion | positive regulation of cell death | cell adhesion | membrane depolarization | morphogenesis of embryonic epithelium | regulation of response to DNA damage stimulus | immune response | nucleobase-containing compound metabolic process | protein kinase activity | cellular response to reactive oxygen species | neuron projection development | regulation of non-canonical Wnt signaling pathway | positive regulation of cellular component biogenesis | organic substance metabolic process | regulation of sequestering of calcium ion | cell death | animal organ development | positive regulation of ion transport | response to reactive oxygen species | positive regulation of cell-substrate adhesion | negative regulation of cellular protein metabolic process | T cell proliferation | regulation of cell activation | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | positive regulation of kinase activity | alpha-beta T cell activation | ion homeostasis | positive regulation of actin binding | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | cytoskeleton organization | regulation of ion transmembrane transport | antigen receptor-mediated signaling pathway | positive regulation of binding | Bergmann glial cell differentiation | establishment of protein localization | positive regulation of cytokine production | negative regulation of cell aging | positive regulation of endothelial cell migration | cell activation | positive regulation of MAPK cascade | positive regulation of protein transport | anatomical structure formation involved in morphogenesis | regulation of stress fiber assembly | negative regulation of cell cycle | negative regulation of protein metabolic process | regulation of epithelial cell migration | lymphocyte proliferation | non-membrane spanning protein tyrosine kinase activity | regulation of cell communication | regulation of blood vessel endothelial cell migration | negative regulation of molecular function | negative regulation of signal transduction | negative regulation of cellular senescence | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | regulation of protein binding | response to organic cyclic compound | neuromuscular process | cell development | positive regulation of cell migration involved in sprouting angiogenesis | regulation of endocytosis | regulation of developmental growth | protein localization | B cell activation involved in immune response | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cell size | regulation of cytokine production | regulation of Ras protein signal transduction | anatomical structure morphogenesis | regulation of actin filament bundle assembly | positive regulation of calcium ion transport into cytosol | negative regulation of phospholipase C activity | response to biotic stimulus | regulation of nervous system development | regulation of developmental process | regulation of ion transport | regulation of Wnt signaling pathway, planar cell polarity pathway | kinase activity | developmental process | organelle organization | regulation of muscle cell differentiation | Fc receptor signaling pathway | regulation of cell growth | transitional one stage B cell differentiation | regulation of calcium ion transport | positive regulation of Wnt signaling pathway, planar cell polarity pathway | positive regulation of interleukin-2 secretion | cellular protein modification process | B cell proliferation | positive regulation of actin filament binding | Fc receptor mediated stimulatory signaling pathway | positive regulation of interleukin-2 production | tube development | regulation of cell junction assembly | regulation of transport | regulation of cell-cell adhesion | developmental cell growth | response to organonitrogen compound | cellular metal ion homeostasis | tube closure | epithelial cell differentiation | heterocycle metabolic process | negative regulation of hydrolase activity | tube formation | cellular response to dopamine | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | regulation of actin filament-based process | regulation of synaptic plasticity | regulation of cell projection organization | regulation of interferon-gamma production | immune system process | positive regulation of Wnt signaling pathway | cellular metabolic process | hematopoietic or lymphoid organ development | ameboidal-type cell migration | cellular response to organic substance | regulation of protein localization | regulation of cell death | positive regulation of cell motility | regulation of substrate adhesion-dependent cell spreading | positive regulation of cell morphogenesis involved in differentiation | neuropilin signaling pathway | negative regulation of cell death | positive regulation of interferon-gamma secretion | circulatory system development | B-1 B cell homeostasis | divalent inorganic cation homeostasis | phagocytosis | positive regulation of angiogenesis | regulation of microtubule cytoskeleton organization | positive regulation of substrate adhesion-dependent cell spreading | regulation of I-kappaB kinase/NF-kappaB signaling | regulation of cellular component organization | positive regulation of calcium ion transport | regulation of cytoskeleton organization | response to other organism | positive regulation of signaling | cellular response to catecholamine stimulus | signal transduction | regulation of signaling | negative regulation of endothelial cell apoptotic process | regulation of cell-matrix adhesion | cellular response to lipopolysaccharide | macromolecule metabolic process | regulation of cellular senescence | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | organelle membrane | nuclear membrane | cell body | cell | nuclear lumen | neuronal cell body | nucleolus | cytoplasm | intracellular organelle | actin cytoskeleton | nuclear body | dendritic tree | protein-containing complex | cell projection | endomembrane system | postsynapse | nucleoplasm | nuclear envelope | cell leading edge | perinuclear region of cytoplasm | mitochondrion | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular | membrane
