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QuickView for c-erbB2 (gene)


Gene Symbol:
Erbb2 Mus musculus Mus musculus
Full name:
erb-b2 receptor tyrosine kinase 2
Synonyms:
Erbb-2, HER-2, HER2, Neu, c-erbB2, c-neu, l11Jus8, mKIAA3023, receptor tyrosine-protein kinase erbB-2, Neu oncogene, avian erythroblastosis oncogene B 2, c-erbB-2, p185erbB2, proto-oncogene NEU, proto-oncogene c-ErbB-2, v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
Genomic Location:
Chr 11: 98273798-98299030
Orthologs:
Homo sapiens Rattus norvegicus Macaca mulatta Danio rerio Canis lupus familiaris Gallus gallus Pan troglodytes Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:


Transcripts Names
NM_001003817
Protein Names
Q61525
P70424
Q6ZPE0
A2A557



GO Molecular Function

transmembrane receptor protein tyrosine kinase activity | RNA polymerase binding | transmembrane signaling receptor activity | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | growth factor binding | catalytic activity | ATP binding | ubiquitin-like protein ligase binding | anion binding | adenyl nucleotide binding | signaling receptor activity | purine nucleotide binding | RNA polymerase core enzyme binding | identical protein binding | protein heterodimerization activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein tyrosine kinase activity | protein binding | RNA polymerase I core binding | protein phosphatase binding | ubiquitin protein ligase binding | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | Hsp90 protein binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | phosphatase binding | heat shock protein binding | heterocyclic compound binding | protein C-terminus binding | small molecule binding

GO Biological Process

negative regulation of lymphocyte differentiation | RNA metabolic process | negative regulation of leukocyte activation | regulation of ERK1 and ERK2 cascade | cell morphogenesis | positive regulation of macromolecule biosynthetic process | regulation of intracellular protein transport | negative regulation of immune system process | positive regulation of Ras protein signal transduction | neuron projection morphogenesis | regulation of cellular localization | intracellular signal transduction | regulation of localization | regulation of programmed cell death | peptidyl-amino acid modification | transmembrane receptor protein tyrosine kinase activity | regulation of transcription by RNA polymerase I | regulation of immune system process | regulation of immature T cell proliferation in thymus | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | regulation of MAP kinase activity | regulation of protein localization to membrane | cell differentiation | positive regulation of epithelial cell proliferation | regulation of T cell differentiation | nervous system development | cell part morphogenesis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | peptidyl-tyrosine phosphorylation | generation of neurons | positive regulation of GTPase activity | positive regulation of cellular biosynthetic process | cellular process | peripheral nervous system development | axon ensheathment | cell projection morphogenesis | negative regulation of signaling | neuron development | multicellular organismal reproductive process | positive regulation of protein kinase activity | negative regulation of apoptotic process | axon guidance | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of T cell proliferation | regulation of transcription by RNA polymerase III | regulation of cell differentiation | autonomic nervous system development | regulation of cellular process | positive regulation of cell growth | regulation of apoptotic process | regulation of metabolic process | gliogenesis | negative regulation of mononuclear cell proliferation | organic cyclic compound metabolic process | positive regulation of translation | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | cell morphogenesis involved in neuron differentiation | regulation of cellular protein localization | positive regulation of protein metabolic process | negative regulation of cell adhesion | positive regulation of phosphatidylinositol 3-kinase signaling | response to stress | neuron projection guidance | negative regulation of lymphocyte activation | positive regulation of cellular protein localization | cellular nitrogen compound biosynthetic process | posttranscriptional regulation of gene expression | regulation of cell proliferation | ovulation cycle | ensheathment of neurons | phosphatidylinositol-mediated signaling | positive regulation of transcription by RNA polymerase III | reproduction | rhythmic process | cellular nitrogen compound metabolic process | regulation of protein transport | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | negative regulation of hemopoiesis | protein modification process | regulation of peptide transport | negative regulation of immature T cell proliferation | regulation of cell adhesion | cellular biosynthetic process | macromolecule modification | regulation of intracellular transport | regulation of lymphocyte differentiation | regulation of nucleic acid-templated transcription | locomotion | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | myelination | multicellular organism development | regulation of MAPK cascade | phosphorus metabolic process | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | wound healing | regulation of T cell activation | regulation of small GTPase mediated signal transduction | regulation of gene expression | axon development | positive regulation of intracellular protein transport | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | neuromuscular junction development | response to axon injury | protein autophosphorylation | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | enzyme linked receptor protein signaling pathway | positive regulation of intracellular signal transduction | synapse organization | axonogenesis | positive regulation of hydrolase activity | negative regulation of immature T cell proliferation in thymus | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | glial cell differentiation | phosphorylation | inositol lipid-mediated signaling | regulation of GTPase activity | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of protein localization to membrane | sympathetic nervous system development | negative regulation of cell activation | regulation of protein metabolic process | positive regulation of signal transduction | heart development | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of transport | negative regulation of T cell differentiation | regulation of microtubule-based process | protein tyrosine kinase activity | positive regulation of molecular function | cellular response to epidermal growth factor stimulus | neuron differentiation | multicellular organism reproduction | protein metabolic process | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | regulation of hemopoiesis | regulation of kinase activity | response to wounding | regulation of intracellular signal transduction | phosphatidylinositol 3-kinase signaling | anatomical structure development | cell surface receptor signaling pathway | positive regulation of small GTPase mediated signal transduction | cell projection organization | metabolic process | regulation of protein targeting | negative regulation of leukocyte proliferation | regulation of RNA biosynthetic process | negative regulation of programmed cell death | oligodendrocyte differentiation | nucleobase-containing compound metabolic process | protein kinase activity | neuron projection development | organic substance metabolic process | animal organ development | gene expression | regulation of cell activation | positive regulation of transcription by RNA polymerase I | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | regulation of phosphate metabolic process | transcription, DNA-templated | positive regulation of intracellular transport | positive regulation of MAPK cascade | response to epidermal growth factor | positive regulation of protein transport | estrous cycle | regulation of cell communication | negative regulation of signal transduction | signaling | positive regulation of growth | regulation of transcription, DNA-templated | cell development | regulation of T cell proliferation | regulation of epithelial cell proliferation | regulation of T cell differentiation in thymus | positive regulation of phosphorylation | cellular protein metabolic process | regulation of Ras protein signal transduction | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | positive regulation of MAP kinase activity | regulation of developmental process | kinase activity | developmental process | regulation of cell growth | cellular protein modification process | positive regulation of protein targeting to membrane | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | regulation of cell-cell adhesion | positive regulation of nucleic acid-templated transcription | heterocycle metabolic process | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | negative regulation of lymphocyte proliferation | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | regulation of translation | negative regulation of cell death | circulatory system development | chemotaxis | negative regulation of T cell differentiation in thymus | motor neuron axon guidance | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of signaling | signal transduction | regulation of phosphatidylinositol 3-kinase signaling | regulation of signaling | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | basal plasma membrane | intracellular membrane-bounded organelle | synapse | apical plasma membrane | organelle membrane | cytoplasmic vesicle | basal part of cell | actin-based cell projection | cell | intrinsic component of membrane | synaptic membrane | cytoplasm | intracellular organelle | receptor complex | membrane microdomain | apical part of cell | endosome membrane | protein-containing complex | cell projection | postsynaptic membrane | endomembrane system | postsynapse | plasma membrane | lateral loop | membrane raft | vesicle | perinuclear region of cytoplasm | integral component of plasma membrane | endosome | microvillus | membrane-bounded organelle | nucleus | organelle | cell periphery | basolateral plasma membrane | cytosol | intracellular vesicle | intracellular | myelin sheath | membrane | intrinsic component of plasma membrane