QuickView for cGKII (gene)
- Gene Symbol:
- PRKG2
Homo sapiens - Full name:
- protein kinase, cGMP-dependent, type II
- Synonyms:
- PRKGR2, cGK2, cGKII, cGMP-dependent protein kinase 2, cGMP-dependent protein kinase II, testicular tissue protein Li 99
- Genomic Location:
- Chr 4: 82228861-82345239
- Description:
-
This gene encodes a protein that belongs to the serine/threonine protein kinase family of proteins. The encoded protein plays a role in the regulation of fluid balance in the intestine. A similar protein in mouse is thought to regulate differentiation and proliferation of cells in the colon. Alternate splicing results in multiple transcript variant...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
4q21.21
GO Molecular Function
guanyl ribonucleotide binding | cGMP-dependent protein kinase activity | cyclic nucleotide binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | cGMP binding | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | protein dimerization activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | heterocyclic compound binding | guanyl nucleotide binding | small molecule binding
GO Biological Process
protein localization to cell periphery | regulation of localization | peptidyl-amino acid modification | cGMP-dependent protein kinase activity | cellular process | localization | macromolecule localization | regulation of cellular process | response to stimulus | regulation of chloride transport | negative regulation of chloride transport | protein serine/threonine kinase activity | cellular localization | negative regulation of transport | cofactor metabolic process | protein modification process | macromolecule modification | nitrogen compound metabolic process | phosphorus metabolic process | protein localization to plasma membrane | protein localization to membrane | protein autophosphorylation | phosphorylation | negative regulation of ion transport | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | protein metabolic process | peptidyl-serine autophosphorylation | metabolic process | cellular protein localization | protein kinase activity | organic substance metabolic process | signaling | protein localization | cellular protein metabolic process | cellular macromolecule localization | regulation of ion transport | kinase activity | peptidyl-serine phosphorylation | cellular protein modification process | regulation of transport | regulation of anion transport | cellular metabolic process | signal transduction | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | apical plasma membrane | organelle membrane | nuclear membrane | cell | cytoplasm | intracellular organelle | apical part of cell | endomembrane system | plasma membrane | nuclear envelope | membrane-bounded organelle | nucleus | organelle | cell periphery | cytosol | intracellular | membrane
