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PubChem
Name: Calcium Carbonate
PubChem Compound ID: 10112
Description: Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.
Molecular formula: CCaO3
Molecular weight: 100.087 g/mol
Synonyms:
Franklin; EPA Pesticide Chemical Code 073502; Neolite F; Calopake PC; Hakuenka CCR; CHEBI:3311; C 50 (carbonate); Eskalon 200; Chooz; Kalziumkarbonat.
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DrugBank
Identification
Name: Calcium Carbonate
Name (isomeric): DB06724
Drug Type: small molecule
Description: Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.
Category: Antacids
Pharmacology
Indication: For relief of heartburn and acid indigestion. May also be used as a nutritional supplement or to treat hypocalcemia.
Pharmacology:
Gastric-peptic disease occurs as a result of an imbalance between protective factors, such as mucus, bicarbonate, and prostaglandin secretion, and aggressive factors, such as hydrochloric acid, pepsin, and Helicobacter pylori (H. pylori). Antacids work by restoring acid-base balance, attenuating the pepsin activity and increasing bica...
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Mechanism of Action:
Calcium carbonate is a basic inorganic salt that acts by neutralizing hydrochloric acid in gastric secretions. It also inhibits the action of pepsin by increasing the pH and via adsorption. Cytoprotective effects may occur through increases in bicarbonate ion (HCO3-) and prostaglandins. Neutralization of hydrochloric acid resu...
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Absorption: Maximal absorption occurs at doses of 500 mg or less taken with food. Oral bioavailability depends on intestinal pH, the presence of food and dosage.
Protein binding: Calcium acts as a co-factor to numerous enzymes.
Biotransformation: None.
Route of elimination: Excreted mainly in the feces. The majority of renally filtered calcium is reabsorbed in the ascending limb of the loop of Henle and the proximal and distal convoluted tubules. Also secreted by sweat glands.
Affected organisms: Humans and other mammals
Interactions
Food interaction:
Food increases the absorption of calcium carbonate.
Drug interaction:
Calcium ChlorideCalcium salts may enhance the adverse/toxic effect of calcium chloride. Concurrent use of other calcium salts with calcium acetate should be avoided when possible. This combination is particularly dangerous in patients with other risk factors for hypercalcemia, such as those with end-stage renal disease.
ItraconazoleThe antacid, calcium carbonate, may decrease the effect of itraconazole by decreasing its absorption.
Calcium AcetateCalcium salts may enhance the adverse/toxic effect of calcium acetate. Concurrent use of other calcium salts with calcium acetate should be avoided when possible. This combination is particularly dangerous in patients with other risk factors for hypercalcemia, such as those with end-stage renal disease.