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QuickView for camptothecin (compound)
PubChem
| Name: | Camptothecin |
|---|---|
| PubChem Compound ID: | 10497972 |
| Description: | An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity. |
| Molecular formula: | C20H16N2O4 |
| Molecular weight: | 349.358 g/mol |
DrugBank
Identification
| Name: | Camptothecin |
|---|---|
| Name (isomeric): | DB04690 |
| Drug Type: | small molecule |
| Description: | An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity. |
| Synonyms: |
(+)-camptothecin; (s)-camptothecin; D-camptothecin; CPT; 20(S)-Camptothecin; 21,22-Secocamptothecin-21-oic acid lactone; Camptothecine; (+)-camptothecine; (s)-(+)-camptothecin
|
| Category: | Enzyme Inhibitors, Antineoplastic Agents, Phytogenic |
| CAS number: | 7689-03-4 |
Pharmacology
| Indication: | Investigated for the treatment of cancer. |
|---|---|
| Pharmacology: | Camptothecin demonstrated strong anticancer activity in preliminary clinical trials but also low solubility and adverse drug reaction. Camptothecin is believed to be a potent topoisomerase inhibitor that interferes with the essential function of topoisomerase in DNA replication. |
| Mechanism of Action: | Camptothecin binds to the topoisomerase I and DNA complex (the covalent complex) resulting in a ternary complex, and thereby stabilizing it. This prevents DNA relegation and therefore causes DNA damage which results in apoptosis. |
| Toxicity: | Acute oral toxicity (LD50) in mouse: 50.1 mg/kg |
| Affected organisms: | Humans and other mammals |
Targets
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