QuickView for carbonic anhydrase IX (gene)

Gene Symbol:

CA9 Homo sapiens

Full name:

carbonic anhydrase 9

Synonyms:

CAIX, MN, carbonic anhydrase 9, CA-IX, P54/58N, RCC-associated antigen G250, RCC-associated protein G250, carbonate dehydratase IX, carbonic anhydrase IX, carbonic dehydratase, membrane antigen MN, pMW1, renal cell carcinoma-associated antigen G250

Genomic Location:

Chr 9: 35663915-35671152

Description:

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show ex...

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Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA IX is a transmembrane protein and is one of only two tumor-associated carbonic anhydrase isoenzymes known. It is expressed in all clear-cell renal cell carcinoma, but is not detected in normal kidney or most other normal tissues. It may be involved in cell proliferation and transformation. This gene was mapped to 17q21.2 by fluorescence in situ hybridization, however, radiation hybrid mapping localized it to 9p13-p12.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AP1_C ,  TGANTCA_AP1_C ,  AP1_Q6 ,  ZIC3_01 ,  GGGAGGRR_MAZ_Q6 ,  P53_02 ,  CAGGTG_E12_Q6 ,  AP1_01 ,  AP1FJ_Q2 ,  ZID_01 ,  BACH2_01 ,  AP1_Q2_01 ,  HIF1_Q5 ,  AP1_Q4 ,  GATA1_05 ,  CP2_02 ,  ZIC2_01 ,  SMAD4_Q6 ,  PAX_Q6 ,  AP1_Q2 ,  CTTTGT_LEF1_Q2 ,  HIF1_Q3 ,  NFKB_C ,  CP2_01 ,  TGASTMAGC_NFE2_01

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Cytogenetic Map:

9p13.3

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