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QuickView for caspase-3 (gene)


Gene Symbol:
CASP3 Homo sapiens Homo sapiens
Full name:
caspase 3
Synonyms:
CPP32, CPP32B, SCA-1, caspase-3, CASP-3, CPP-32, PARP cleavage protease, SREBP cleavage activity 1, apopain, caspase 3, apoptosis-related cysteine peptidase, caspase 3, apoptosis-related cysteine protease, cysteine protease CPP32, procaspase3, protein Yama
Genomic Location:
Chr 4: 185785844-185807623
Description:
The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed ...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Macaca mulatta Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes Danio rerio
External Links:
Entrez Gene
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 4
4q35.1





GO Molecular Function

enzyme activator activity | protein kinase regulator activity | protein serine/threonine kinase inhibitor activity | cysteine-type endopeptidase activity involved in apoptotic signaling pathway | lipase activator activity | kinase regulator activity | protein kinase inhibitor activity | cysteine-type endopeptidase activity involved in apoptotic process | enzyme binding | protein-containing complex binding | peptidase activator activity | aspartic-type peptidase activity | enzyme inhibitor activity | signaling receptor binding | hydrolase activity | cytokine receptor binding | cysteine-type peptidase activity | molecular function regulator | catalytic activity | cysteine-type endopeptidase activity involved in execution phase of apoptosis | death receptor binding | peptidase activator activity involved in apoptotic process | phospholipase A2 activator activity | cysteine-type endopeptidase activity | protein binding | aspartic-type endopeptidase activity | kinase inhibitor activity | phospholipase activator activity | cysteine-type endopeptidase regulator activity involved in apoptotic process | endopeptidase activity | enzyme regulator activity | cyclin-dependent protein serine/threonine kinase inhibitor activity | protease binding | cysteine-type endopeptidase activator activity involved in apoptotic process | tumor necrosis factor receptor superfamily binding | peptidase activity | cyclin-dependent protein serine/threonine kinase regulator activity

GO Biological Process

leukocyte homeostasis | negative regulation of leukocyte activation | negative regulation of phosphorylation | brain development | response to radiation | cell morphogenesis | regulation of cysteine-type endopeptidase activity | negative regulation of immune system process | response to cytokine | regulation of B cell activation | negative regulation of activated T cell proliferation | response to lipopolysaccharide | intracellular signal transduction | enzyme activator activity | positive regulation of apoptotic process | proteolysis | protein kinase regulator activity | regulation of programmed cell death | erythrocyte homeostasis | response to X-ray | hippocampus development | regulation of autophagy | regulation of immune system process | response to hormone | myeloid cell differentiation | neuron death | negative regulation of cellular process | negative regulation of kinase activity | negative regulation of leukocyte cell-cell adhesion | protein processing | response to metal ion | cell differentiation | protein serine/threonine kinase inhibitor activity | cysteine-type endopeptidase activity involved in apoptotic signaling pathway | nervous system development | negative regulation of B cell proliferation | response to drug | negative regulation of protein phosphorylation | neurogenesis | lipase activator activity | generation of neurons | response to antibiotic | sensory perception of mechanical stimulus | regulation of neuron death | cellular process | organic substance catabolic process | DNA catabolic process, endonucleolytic | extrinsic apoptotic signaling pathway | apoptotic nuclear changes | apoptotic DNA fragmentation | kinase regulator activity | response to estradiol | protein kinase inhibitor activity | cysteine-type endopeptidase activity involved in apoptotic process | immune system development | negative regulation of apoptotic process | response to hypoxia | regulation of proteolysis | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of T cell proliferation | response to inorganic substance | negative regulation of cellular metabolic process | tissue development | intrinsic apoptotic signaling pathway | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | negative regulation of mononuclear cell proliferation | peptidase activator activity | organic cyclic compound metabolic process | aspartic-type peptidase activity | positive regulation of cellular protein metabolic process | epithelium development | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | cellular component organization | response to UV | head development | response to stimulus | enzyme inhibitor activity | positive regulation of protein metabolic process | positive regulation of peptidase activity | negative regulation of cell adhesion | response to stress | negative regulation of lymphocyte activation | negative regulation of protein kinase activity | regulation of cell proliferation | positive regulation of cysteine-type endopeptidase activity | response to glucose | execution phase of apoptosis | programmed cell death | cellular component disassembly involved in execution phase of apoptosis | positive regulation of proteolysis | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | regulation of macroautophagy | nucleic acid phosphodiester bond hydrolysis | cellular response to organic cyclic compound | negative regulation of metabolic process | platelet formation | hemopoiesis | cellular response to staurosporine | regulation of cell adhesion | nucleobase-containing compound catabolic process | cysteine-type peptidase activity | molecular function regulator | myeloid cell homeostasis | response to nitrogen compound | apoptotic process | response to light stimulus | response to nicotine | response to external biotic stimulus | system development | regulation of cyclin-dependent protein serine/threonine kinase activity | response to oxygen levels | nitrogen compound metabolic process | cysteine-type endopeptidase activity involved in execution phase of apoptosis | negative regulation of phosphate metabolic process | multicellular organism development | negative regulation of catalytic activity | regulation of peptidase activity | response to amino acid | learning or memory | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | wound healing | cellular response to ammonium ion | regulation of T cell activation | telencephalon development | regulation of activated T cell proliferation | cellular response to stress | response to lipid | nervous system process | platelet morphogenesis | hippo signaling | negative regulation of cyclin-dependent protein serine/threonine kinase activity | positive regulation of cellular metabolic process | regulation of lymphocyte activation | response to ammonium ion | glial cell apoptotic process | regulation of nitrogen compound metabolic process | negative regulation of T cell activation | enzyme linked receptor protein signaling pathway | neuron apoptotic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | cytokine-mediated signaling pathway | negative regulation of protein serine/threonine kinase activity | response to corticosteroid | cellular response to alkaloid | response to oxidative stress | peptidase activator activity involved in apoptotic process | B cell homeostasis | positive regulation of hydrolase activity | cognition | epidermal cell differentiation | homeostasis of number of cells | cellular response to cytokine stimulus | phospholipase A2 activator activity | response to osmotic stress | regulation of cellular protein metabolic process | neurotrophin signaling pathway | positive regulation of endopeptidase activity | positive regulation of neuron death | protein maturation | epidermis development | response to toxic substance | skin development | cell morphogenesis involved in differentiation | keratinocyte differentiation | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | response to bacterium | negative regulation of cell-cell adhesion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | regulation of neuron apoptotic process | lymphocyte homeostasis | negative regulation of cell activation | sensory perception of sound | regulation of protein metabolic process | aromatic compound catabolic process | heart development | homeostatic process | limbic system development | response to monosaccharide | regulation of protein phosphorylation | cysteine-type endopeptidase activity | apoptotic signaling pathway | negative regulation of B cell activation | positive regulation of molecular function | neuron differentiation | negative regulation of cyclin-dependent protein kinase activity | protein metabolic process | response to organic substance | neurotrophin TRK receptor signaling pathway | aspartic-type endopeptidase activity | kinase inhibitor activity | regulation of kinase activity | response to wounding | DNA metabolic process | cellular response to osmotic stress | cellular macromolecule catabolic process | positive regulation of neuron apoptotic process | anatomical structure development | cell surface receptor signaling pathway | metabolic process | cell fate commitment | activation of cysteine-type endopeptidase activity involved in apoptotic process | negative regulation of leukocyte proliferation | negative regulation of programmed cell death | behavior | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | animal organ development | response to reactive oxygen species | forebrain development | pallium development | negative regulation of cellular protein metabolic process | gene expression | regulation of cell activation | positive regulation of programmed cell death | regulation of phosphate metabolic process | response to alkaloid | intrinsic apoptotic signaling pathway in response to osmotic stress | T cell homeostasis | phospholipase activator activity | anatomical structure formation involved in morphogenesis | negative regulation of cell cycle | negative regulation of protein metabolic process | sensory perception | cysteine-type endopeptidase regulator activity involved in apoptotic process | negative regulation of molecular function | signaling | response to organic cyclic compound | endopeptidase activity | cell development | regulation of T cell proliferation | extrinsic apoptotic signaling pathway in absence of ligand | enzyme regulator activity | anatomical structure morphogenesis | regulation of endopeptidase activity | response to biotic stimulus | DNA catabolic process | developmental process | cyclin-dependent protein serine/threonine kinase inhibitor activity | erythrocyte differentiation | regulation of B cell proliferation | negative regulation of cell proliferation | regulation of cell-cell adhesion | cysteine-type endopeptidase activator activity involved in apoptotic process | response to organonitrogen compound | epithelial cell differentiation | response to cobalt ion | heterocycle metabolic process | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | negative regulation of lymphocyte proliferation | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | peptidase activity | response to tumor necrosis factor | cellular response to organic substance | regulation of cell death | response to carbohydrate | response to steroid hormone | negative regulation of cell death | circulatory system development | response to ionizing radiation | response to other organism | signal transduction | response to glucocorticoid | cellular response to growth factor stimulus | cyclin-dependent protein serine/threonine kinase regulator activity | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | plasma membrane protein complex | cytoplasm | death-inducing signaling complex | intracellular organelle | membrane microdomain | protein-containing complex | nucleoplasm | plasma membrane | membrane raft | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | cytosol | intracellular | membrane