QuickView for cbl2 (gene)

Gene Symbol:

CBL Homo sapiens

Full name:

Cbl proto-oncogene

Synonyms:

C-CBL, CBL2, FRA11B, NSLL, RNF55, E3 ubiquitin-protein ligase CBL, Cas-Br-M (murine) ecotropic retroviral transforming sequence, Cbl proto-oncogene, E3 ubiquitin protein ligase, RING finger protein 55, RING-type E3 ubiquitin transferase CBL, casitas B-lineage lymphoma proto-oncogene, fragile site, folic acid type, rare, fra(11)(q23.3), oncogene CBL2, proto-oncogene c-Cbl, signal transduction protein CBL

Genomic Location:

Chr 11: 118582200-118684069

Description:

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphot...

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This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GAGCCTG_MIR484 ,  TGGNNNNNNKCCAR_UNKNOWN ,  AML_Q6 ,  CTACTGT_MIR199A ,  GGGACCA_MIR133A_MIR133B ,  PEA3_Q6 ,  CAGTGTT_MIR141_MIR200A ,  GTACTGT_MIR101 ,  STAT6_01 ,  AML1_01 ,  ATAGGAA_MIR202 ,  STAT_Q6 ,  TAGGTCA_MIR192_MIR215 ,  ACATTCC_MIR1_MIR206 ,  ATACCTC_MIR202 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  GTTTGTT_MIR495 ,  GGGCGGR_SP1_Q6 ,  STAT5A_03 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  GATA1_02 ,  RACCACAR_AML_Q6 ,  STAT_01 ,  GTGCCTT_MIR506 ,  AML1_Q6 ,  GGCAGCT_MIR22 ,  CCTGCTG_MIR214 ,  CART1_01 ,  SCGGAAGY_ELK1_02 ,  GATA4_Q3 ,  TTCYNRGAA_STAT5B_01 ,  CTTTGT_LEF1_Q2 ,  BRN2_01 ,  COREBINDINGFACTOR_Q6 ,  AGGAAGC_MIR5163P ,  ACACTGG_MIR199A_MIR199B

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-192 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-338 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-542-3p ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

11q23.3

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