QuickView for cca (gene)
- Gene Symbol:
- FBN2
Homo sapiens - Full name:
- fibrillin 2
- Synonyms:
- CCA, DA9, EOMD, fibrillin-2, fibrillin 5
- Genomic Location:
- Chr 5: 127621500-127901634
- Description:
-
The protein encoded by this gene is a component of connective tissue microfibrils and may be involved in elastic fiber assembly. Mutations in this gene cause congenital contractural arachnodactyly.
- Orthologs:
- Mus musculus , Rattus norvegicus , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-101 , Predicted Gene Targets for miR-136 , Predicted Gene Targets for miR-139 , Predicted Gene Targets for miR-144 , Predicted Gene Targets for miR-204 , Predicted Gene Targets for miR-217 , Predicted Gene Targets for miR-218 , Predicted Gene Targets for miR-22 , Predicted Gene Targets for miR-221 , Predicted Gene Targets for miR-23
- Cytogenetic Map:
-
5q23.3
GO Molecular Function
structural molecule activity | cation binding | ion binding | protein binding | structural molecule activity conferring elasticity | extracellular matrix constituent conferring elasticity | calcium ion binding | metal ion binding | extracellular matrix structural constituent
GO Biological Process
limb development | extracellular structure organization | eye development | regulation of transforming growth factor beta receptor signaling pathway | negative regulation of cellular process | positive regulation of developmental process | embryonic appendage morphogenesis | positive regulation of biomineral tissue development | cellular process | localization | limb morphogenesis | negative regulation of signaling | macromolecule localization | regulation of bone mineralization | regulation of cell differentiation | regulation of cellular process | regulation of osteoblast differentiation | trabecula morphogenesis | sequestering of TGFbeta in extracellular matrix | cellular component organization | embryonic limb morphogenesis | extracellular matrix organization | embryo development | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | negative regulation of cellular response to transforming growth factor beta stimulus | system development | regulation of signal transduction | multicellular organism development | regulation of ossification | extracellular negative regulation of signal transduction | animal organ morphogenesis | negative regulation of cellular response to growth factor stimulus | sequestering of extracellular ligand from receptor | positive regulation of cell differentiation | bone trabecula formation | positive regulation of ossification | sensory organ development | maintenance of protein location | eye morphogenesis | skeletal system morphogenesis | regulation of cellular response to growth factor stimulus | embryonic morphogenesis | positive regulation of osteoblast differentiation | embryonic organ morphogenesis | negative regulation of transforming growth factor beta receptor signaling pathway | anatomical structure development | embryonic organ development | bone trabecula morphogenesis | animal organ development | camera-type eye development | anatomical structure formation involved in morphogenesis | regulation of cell communication | negative regulation of signal transduction | protein localization | anatomical structure morphogenesis | regulation of developmental process | developmental process | skeletal system development | embryonic eye morphogenesis | positive regulation of bone mineralization | regulation of signaling | multicellular organismal process
GO Cellular Component
supramolecular fiber | extracellular matrix | collagen-containing extracellular matrix | extracellular region | microfibril | supramolecular complex
